Human Blood-Derived lncRNAs in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder with a significant impact on public health. ASD diagnosis is based on clinical observation and typically occurs around three years of age. The identification of reliable ASD markers could facilitate early diagn...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/7/937 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850077683670581248 |
|---|---|
| author | Carmela Serpe Paola De Sanctis Marina Marini Silvia Canaider Provvidenza Maria Abruzzo Cinzia Zucchini |
| author_facet | Carmela Serpe Paola De Sanctis Marina Marini Silvia Canaider Provvidenza Maria Abruzzo Cinzia Zucchini |
| author_sort | Carmela Serpe |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder with a significant impact on public health. ASD diagnosis is based on clinical observation and typically occurs around three years of age. The identification of reliable ASD markers could facilitate early diagnosis and help pinpoint therapeutic targets for effective interventions. Long non-coding RNAs (lncRNAs), particularly those derived from blood, have been recently proposed as potential biomarkers in many pathological conditions, including neurological diseases. This manuscript summarizes original studies examining human dysregulated blood-derived lncRNAs as potential ASD biomarkers. LncRNAs are described by grouping them according to the selection strategy used by the authors: (i) lncRNAs involved in biological processes impaired in ASD or in pathological conditions sharing the disrupted signaling pathways of ASD; and (ii) lncRNAs identified through high-throughput analysis. The study highlights key priorities for future research: assessing the ability of lncRNAs to distinguish ASD from other neurological disorders, extending analyses to larger and younger cohorts to validate candidate biomarkers in early life, and integrating multiple data sources to establish validated biomarker networks for clinical application. This review indicates that research on blood-derived lncRNAs in ASD is still in its early stages. |
| format | Article |
| id | doaj-art-3850c46bfb014bef963f2071eadf3351 |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-3850c46bfb014bef963f2071eadf33512025-08-20T02:45:45ZengMDPI AGBiomolecules2218-273X2025-06-0115793710.3390/biom15070937Human Blood-Derived lncRNAs in Autism Spectrum DisorderCarmela Serpe0Paola De Sanctis1Marina Marini2Silvia Canaider3Provvidenza Maria Abruzzo4Cinzia Zucchini5Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyAutism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder with a significant impact on public health. ASD diagnosis is based on clinical observation and typically occurs around three years of age. The identification of reliable ASD markers could facilitate early diagnosis and help pinpoint therapeutic targets for effective interventions. Long non-coding RNAs (lncRNAs), particularly those derived from blood, have been recently proposed as potential biomarkers in many pathological conditions, including neurological diseases. This manuscript summarizes original studies examining human dysregulated blood-derived lncRNAs as potential ASD biomarkers. LncRNAs are described by grouping them according to the selection strategy used by the authors: (i) lncRNAs involved in biological processes impaired in ASD or in pathological conditions sharing the disrupted signaling pathways of ASD; and (ii) lncRNAs identified through high-throughput analysis. The study highlights key priorities for future research: assessing the ability of lncRNAs to distinguish ASD from other neurological disorders, extending analyses to larger and younger cohorts to validate candidate biomarkers in early life, and integrating multiple data sources to establish validated biomarker networks for clinical application. This review indicates that research on blood-derived lncRNAs in ASD is still in its early stages.https://www.mdpi.com/2218-273X/15/7/937long non-coding RNAlncRNAautism spectrum disorderASDbiomarkersnon-coding RNA |
| spellingShingle | Carmela Serpe Paola De Sanctis Marina Marini Silvia Canaider Provvidenza Maria Abruzzo Cinzia Zucchini Human Blood-Derived lncRNAs in Autism Spectrum Disorder Biomolecules long non-coding RNA lncRNA autism spectrum disorder ASD biomarkers non-coding RNA |
| title | Human Blood-Derived lncRNAs in Autism Spectrum Disorder |
| title_full | Human Blood-Derived lncRNAs in Autism Spectrum Disorder |
| title_fullStr | Human Blood-Derived lncRNAs in Autism Spectrum Disorder |
| title_full_unstemmed | Human Blood-Derived lncRNAs in Autism Spectrum Disorder |
| title_short | Human Blood-Derived lncRNAs in Autism Spectrum Disorder |
| title_sort | human blood derived lncrnas in autism spectrum disorder |
| topic | long non-coding RNA lncRNA autism spectrum disorder ASD biomarkers non-coding RNA |
| url | https://www.mdpi.com/2218-273X/15/7/937 |
| work_keys_str_mv | AT carmelaserpe humanbloodderivedlncrnasinautismspectrumdisorder AT paoladesanctis humanbloodderivedlncrnasinautismspectrumdisorder AT marinamarini humanbloodderivedlncrnasinautismspectrumdisorder AT silviacanaider humanbloodderivedlncrnasinautismspectrumdisorder AT provvidenzamariaabruzzo humanbloodderivedlncrnasinautismspectrumdisorder AT cinziazucchini humanbloodderivedlncrnasinautismspectrumdisorder |