Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine
We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. Afte...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2016/4626279 |
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| author | John P. O’Laughlin Parag H. Mehta Brian C. Wong |
| author_facet | John P. O’Laughlin Parag H. Mehta Brian C. Wong |
| author_sort | John P. O’Laughlin |
| collection | DOAJ |
| description | We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used. The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure. |
| format | Article |
| id | doaj-art-384aed06ae9548f2ab3f6719cd39c438 |
| institution | Kabale University |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-384aed06ae9548f2ab3f6719cd39c4382025-02-03T05:47:47ZengWileyCase Reports in Cardiology2090-64042090-64122016-01-01201610.1155/2016/46262794626279Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to HydroxychloroquineJohn P. O’Laughlin0Parag H. Mehta1Brian C. Wong2New York Methodist Hospital, Department of Internal Medicine, 506 6th Street, Brooklyn, NY 11215, USANew York Methodist Hospital, Department of Internal Medicine, 506 6th Street, Brooklyn, NY 11215, USANew York Methodist Hospital, Department of Internal Medicine, Division of Cardiology, 506 6th Street, Brooklyn, NY 11215, USAWe present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used. The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure.http://dx.doi.org/10.1155/2016/4626279 |
| spellingShingle | John P. O’Laughlin Parag H. Mehta Brian C. Wong Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine Case Reports in Cardiology |
| title | Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine |
| title_full | Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine |
| title_fullStr | Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine |
| title_full_unstemmed | Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine |
| title_short | Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine |
| title_sort | life threatening severe qtc prolongation in patient with systemic lupus erythematosus due to hydroxychloroquine |
| url | http://dx.doi.org/10.1155/2016/4626279 |
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