Comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non-alcoholic fatty liver disease
Aim: Coronary heart disease (CHD) has been the leading cause of death worldwide for several decades. Non-alcoholic fatty liver disease (NAFLD), the most common liver pathology, is considered a risk factor (RF) for the development of CHD and a predictor of an unfavourable prognosis. Our study aimed t...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-06-01
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| Series: | Exploration of Cardiology |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A101260/101260.pdf |
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| author | Dilnora B. Yusupalieva Rano B. Alieva Ulugbek I. Nizamov Aleksandr B. Shek Shoxista Axmedova Nargiza Nurillaeva Surayyo M. Shukurdjanova |
| author_facet | Dilnora B. Yusupalieva Rano B. Alieva Ulugbek I. Nizamov Aleksandr B. Shek Shoxista Axmedova Nargiza Nurillaeva Surayyo M. Shukurdjanova |
| author_sort | Dilnora B. Yusupalieva |
| collection | DOAJ |
| description | Aim: Coronary heart disease (CHD) has been the leading cause of death worldwide for several decades. Non-alcoholic fatty liver disease (NAFLD), the most common liver pathology, is considered a risk factor (RF) for the development of CHD and a predictor of an unfavourable prognosis. Our study aimed to compare cardiometabolic parameters in patients with CHD with and without NAFLD. Methods: The study prospectively included 85 patients with CHD, 61 with NAFLD (group I) and 24 without NAFLD (group II). In both groups, a comparative analysis of RF, anthropometric parameters, lipidogram, glycemic profile, brachiocephalic arteries (BCA) ultrasound (USD), and heart structural and geometric parameters according to echocardiography (EchoCG) and coronary calcium (CC) parameters was performed. Results: Patients with CHD and NAFLD had statistically significantly higher levels of total cholesterol, very low-density lipoproteins, triglycerides, insulin, heart structural parameters, and CC. Conclusions: Thus, the relationship between NAFLD and CHD is two-way, and liver diseases can exacerbate the course of cardiovascular diseases (CVD). |
| format | Article |
| id | doaj-art-3842aa8f044248bd9fd87d404fc60f06 |
| institution | DOAJ |
| issn | 2994-5526 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Cardiology |
| spelling | doaj-art-3842aa8f044248bd9fd87d404fc60f062025-08-20T03:12:28ZengOpen Exploration Publishing Inc.Exploration of Cardiology2994-55262025-06-01310126010.37349/ec.2025.101260Comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non-alcoholic fatty liver diseaseDilnora B. Yusupalieva0https://orcid.org/0009-0009-7116-9755Rano B. Alieva1https://orcid.org/0000-0003-3936-0815Ulugbek I. Nizamov2https://orcid.org/0000-0001-6171-7652Aleksandr B. Shek3https://orcid.org/0000-0003-2354-1785Shoxista Axmedova4https://orcid.org/0009-0003-4640-9936Nargiza Nurillaeva5https://orcid.org/0000-0001-5520-675XSurayyo M. Shukurdjanova6https://orcid.org/0000-0002-3989-1985Republican Specialized Scientific and Practical Medical Center of Cardiology, Tashkent 100052, UzbekistanRepublican Specialized Scientific and Practical Medical Center of Cardiology, Tashkent 100052, UzbekistanRepublican Specialized Scientific and Practical Medical Center of Cardiology, Tashkent 100052, UzbekistanRepublican Specialized Scientific and Practical Medical Center of Cardiology, Tashkent 100052, UzbekistanRepublican Specialized Scientific and Practical Medical Center of Cardiology, Tashkent 100052, UzbekistanTashkent Medical Academy, Tashkent 100169, UzbekistanTashkent Medical Academy, Tashkent 100169, UzbekistanAim: Coronary heart disease (CHD) has been the leading cause of death worldwide for several decades. Non-alcoholic fatty liver disease (NAFLD), the most common liver pathology, is considered a risk factor (RF) for the development of CHD and a predictor of an unfavourable prognosis. Our study aimed to compare cardiometabolic parameters in patients with CHD with and without NAFLD. Methods: The study prospectively included 85 patients with CHD, 61 with NAFLD (group I) and 24 without NAFLD (group II). In both groups, a comparative analysis of RF, anthropometric parameters, lipidogram, glycemic profile, brachiocephalic arteries (BCA) ultrasound (USD), and heart structural and geometric parameters according to echocardiography (EchoCG) and coronary calcium (CC) parameters was performed. Results: Patients with CHD and NAFLD had statistically significantly higher levels of total cholesterol, very low-density lipoproteins, triglycerides, insulin, heart structural parameters, and CC. Conclusions: Thus, the relationship between NAFLD and CHD is two-way, and liver diseases can exacerbate the course of cardiovascular diseases (CVD).https://www.explorationpub.com/uploads/Article/A101260/101260.pdfcoronary heart diseasenon-alcoholic fatty liver diseaselipid profileleft ventricular remodelling |
| spellingShingle | Dilnora B. Yusupalieva Rano B. Alieva Ulugbek I. Nizamov Aleksandr B. Shek Shoxista Axmedova Nargiza Nurillaeva Surayyo M. Shukurdjanova Comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non-alcoholic fatty liver disease Exploration of Cardiology coronary heart disease non-alcoholic fatty liver disease lipid profile left ventricular remodelling |
| title | Comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non-alcoholic fatty liver disease |
| title_full | Comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non-alcoholic fatty liver disease |
| title_fullStr | Comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non-alcoholic fatty liver disease |
| title_full_unstemmed | Comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non-alcoholic fatty liver disease |
| title_short | Comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non-alcoholic fatty liver disease |
| title_sort | comparative analysis of cardiometabolic parameters in patients with coronary heart disease with and without non alcoholic fatty liver disease |
| topic | coronary heart disease non-alcoholic fatty liver disease lipid profile left ventricular remodelling |
| url | https://www.explorationpub.com/uploads/Article/A101260/101260.pdf |
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