Serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity, maternal and perinatal outcomes
Abstract Background Preeclampsia is a rapidly progressing pregnancy-specific multi-systemic syndrome that is the leading cause of maternal and neonatal morbidity and mortality. Lactate dehydrogenase (LDH) is a valuable and potential biomarker for predicting the severity of Preeclampsia. Objectives T...
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2025-03-01
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| Online Access: | https://doi.org/10.1186/s12905-025-03622-5 |
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| author | Sallama Kamel Nasir Rozhan Yassin Khalil Maryam Bakir Mahmood Aveen Saadi Dawd |
| author_facet | Sallama Kamel Nasir Rozhan Yassin Khalil Maryam Bakir Mahmood Aveen Saadi Dawd |
| author_sort | Sallama Kamel Nasir |
| collection | DOAJ |
| description | Abstract Background Preeclampsia is a rapidly progressing pregnancy-specific multi-systemic syndrome that is the leading cause of maternal and neonatal morbidity and mortality. Lactate dehydrogenase (LDH) is a valuable and potential biomarker for predicting the severity of Preeclampsia. Objectives To assess the level of LDH in women with preeclampsia and to correlate its level with the severity of the disease and maternal/perinatal outcomes. Patients and methods This prospective case-control study was conducted at Sulaimani Maternity Teaching Hospital, Sulaimaniyah, Iraq, from March 1st, 2021, to June 30th, 2022, on 150 pregnant women in 3rd trimester of their pregnancy. Patients (n = 100) were diagnosed with mild and severe Preeclampsia. Serum LDH level was measured and correlated with the severity of the disease and maternal/perinatal outcomes. Results LDH was significantly (p = 0.001) elevated in preeclampsia groups compared to the control group. The mild preeclampsia group had a mean LDH level of 302.9 ± 138.5 IU/L, while the severe preeclampsia group had a mean level of 488.6 ± 223.4 IU/L. Also, maternal complications, stillbirth rate, and neonatal intensive Care Unit (NICU) admission were higher in women with high LDH levels. Conclusions The serum LDH level is high in women with preeclampsia and correlated with the disease severity as well as maternal and perinatal outcomes. So, serum LDH may be a valuable biomarker for predicting the severity of preeclampsia. |
| format | Article |
| id | doaj-art-384072ec12de4631bcff03ac2cb64a96 |
| institution | DOAJ |
| issn | 1472-6874 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
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| series | BMC Women's Health |
| spelling | doaj-art-384072ec12de4631bcff03ac2cb64a962025-08-20T02:56:20ZengBMCBMC Women's Health1472-68742025-03-012511710.1186/s12905-025-03622-5Serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity, maternal and perinatal outcomesSallama Kamel Nasir0Rozhan Yassin Khalil1Maryam Bakir Mahmood2Aveen Saadi Dawd3Department of Clinical Medical Sciences, College of Medicine, University of SulaimaniDepartment of Clinical Medical Sciences, College of Medicine, University of SulaimaniDepartment of Clinical Medical Sciences, College of Medicine, University of SulaimaniSulaimani Maternity Teaching Hospital, Sulaimani Directorate of HealthAbstract Background Preeclampsia is a rapidly progressing pregnancy-specific multi-systemic syndrome that is the leading cause of maternal and neonatal morbidity and mortality. Lactate dehydrogenase (LDH) is a valuable and potential biomarker for predicting the severity of Preeclampsia. Objectives To assess the level of LDH in women with preeclampsia and to correlate its level with the severity of the disease and maternal/perinatal outcomes. Patients and methods This prospective case-control study was conducted at Sulaimani Maternity Teaching Hospital, Sulaimaniyah, Iraq, from March 1st, 2021, to June 30th, 2022, on 150 pregnant women in 3rd trimester of their pregnancy. Patients (n = 100) were diagnosed with mild and severe Preeclampsia. Serum LDH level was measured and correlated with the severity of the disease and maternal/perinatal outcomes. Results LDH was significantly (p = 0.001) elevated in preeclampsia groups compared to the control group. The mild preeclampsia group had a mean LDH level of 302.9 ± 138.5 IU/L, while the severe preeclampsia group had a mean level of 488.6 ± 223.4 IU/L. Also, maternal complications, stillbirth rate, and neonatal intensive Care Unit (NICU) admission were higher in women with high LDH levels. Conclusions The serum LDH level is high in women with preeclampsia and correlated with the disease severity as well as maternal and perinatal outcomes. So, serum LDH may be a valuable biomarker for predicting the severity of preeclampsia.https://doi.org/10.1186/s12905-025-03622-5PreeclampsiaSerum lactate dehydrogenaseDisease severityMaternal/perinatal outcomes |
| spellingShingle | Sallama Kamel Nasir Rozhan Yassin Khalil Maryam Bakir Mahmood Aveen Saadi Dawd Serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity, maternal and perinatal outcomes BMC Women's Health Preeclampsia Serum lactate dehydrogenase Disease severity Maternal/perinatal outcomes |
| title | Serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity, maternal and perinatal outcomes |
| title_full | Serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity, maternal and perinatal outcomes |
| title_fullStr | Serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity, maternal and perinatal outcomes |
| title_full_unstemmed | Serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity, maternal and perinatal outcomes |
| title_short | Serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity, maternal and perinatal outcomes |
| title_sort | serum lactate dehydrogenase level in preeclampsia and its correlation with disease severity maternal and perinatal outcomes |
| topic | Preeclampsia Serum lactate dehydrogenase Disease severity Maternal/perinatal outcomes |
| url | https://doi.org/10.1186/s12905-025-03622-5 |
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