Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal Intubation
Objective: To compare mean change in heart rate and arterial pressure in patients undergoing endotracheal intubation receiving 0.5 µg/kg dexmedetomidine versus 1.00 µg/kg dexmedetomidine. Study Design: Randomized control trial. Place and Duration of Study: The study was conducted in main Operation T...
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National University of Medical Sciences
2023-04-01
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| Series: | Life and Science |
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| Online Access: | https://ojs.lifenscience.org/index.php/life-and-science/article/view/334 |
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| author | Tasneem Alam Sanum Kashif Khalid Mehmood Umair . Akhtar Hussain |
| author_facet | Tasneem Alam Sanum Kashif Khalid Mehmood Umair . Akhtar Hussain |
| author_sort | Tasneem Alam |
| collection | DOAJ |
| description | Objective: To compare mean change in heart rate and arterial pressure in patients undergoing endotracheal intubation receiving 0.5 µg/kg dexmedetomidine versus 1.00 µg/kg dexmedetomidine.
Study Design: Randomized control trial.
Place and Duration of Study: The study was conducted in main Operation Theatre of Combined Military Hospital Sialkot, Pakistan from 3rd February 2022 to 30th November 2022.
Material and Methods: A total of 60 patients undergoing elective surgeries under general anesthesia using endotracheal intubation, aged 20 – 60 years of either gender were included. The included patients were divided into two groups using draw randomization. Randomization was done using lottery method. Group I patients received 0.5 µg/kg dexmedetomidine infusion and group II patients received 1.0 µg/kg dexmedetomidine infusion over 10 mins through a controlled infusion device. After endotracheal intubation, mean arterial pressure (MAP) and mean heart rate (HR) were noted after 3 minutes of intubation. Non-probability convenience sampling was used for date collection and SPSS version 23 was used for data analysis.
Result: Out of 60 patients, 26 (43.33%) were males and 34 (56.67%) were females with male to female ratio of 1:1.3, the average age was 42.19 ± 9.87 years and BMI was found 28.88 ± 2.48 kg/m2. In group I (0.5 µg/kg dexmedetomidine infusion), the mean HR and MAP before intubation was 108.43 ± 6.26 bpm, 112.20 ± 8.88 mmHg and after 3 minutes of intubation was 76.20 ± 4.16 bpm, 88.20 ± 3.93 respectively while in group II (1.0 µg/kg dexmedetomidine infusion), the mean HR and MAP before intubation 102.10 ± 10.20 bpm, 109.07 ± 8.35 mmHg and after 3 minutes of intubation was 85.97 ± 3.26 bpm, 97.90 ± 5.74 mmHg respectively.
Conclusion: Higher dose of dexmedetomidine (1.0 ug/kg) significantly attenuates hemodynamic response on endotracheal intubation as compare to lower dose (0.5 µg/kg). |
| format | Article |
| id | doaj-art-38406edfb4ac49baa6c3fae7a1db5116 |
| institution | OA Journals |
| issn | 2521-0475 2708-2970 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | National University of Medical Sciences |
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| series | Life and Science |
| spelling | doaj-art-38406edfb4ac49baa6c3fae7a1db51162025-08-20T02:12:32ZengNational University of Medical SciencesLife and Science2521-04752708-29702023-04-01425510.37185/LnS.1.1.334334Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal IntubationTasneem Alam0Sanum Kashif1Khalid Mehmood2Umair .3Akhtar Hussain4Armed Forces Institute of Urology (AFIU), Rawalpindi, PakistanCombined Military Hospital (CMH), DI Khan, PakistanCombined Military Hospital (CMH), Sialkot, PakistanCombined Military Hospital (CMH), Quetta, PakistanCombined Military Hospital (CMH), Quetta, PakistanObjective: To compare mean change in heart rate and arterial pressure in patients undergoing endotracheal intubation receiving 0.5 µg/kg dexmedetomidine versus 1.00 µg/kg dexmedetomidine. Study Design: Randomized control trial. Place and Duration of Study: The study was conducted in main Operation Theatre of Combined Military Hospital Sialkot, Pakistan from 3rd February 2022 to 30th November 2022. Material and Methods: A total of 60 patients undergoing elective surgeries under general anesthesia using endotracheal intubation, aged 20 – 60 years of either gender were included. The included patients were divided into two groups using draw randomization. Randomization was done using lottery method. Group I patients received 0.5 µg/kg dexmedetomidine infusion and group II patients received 1.0 µg/kg dexmedetomidine infusion over 10 mins through a controlled infusion device. After endotracheal intubation, mean arterial pressure (MAP) and mean heart rate (HR) were noted after 3 minutes of intubation. Non-probability convenience sampling was used for date collection and SPSS version 23 was used for data analysis. Result: Out of 60 patients, 26 (43.33%) were males and 34 (56.67%) were females with male to female ratio of 1:1.3, the average age was 42.19 ± 9.87 years and BMI was found 28.88 ± 2.48 kg/m2. In group I (0.5 µg/kg dexmedetomidine infusion), the mean HR and MAP before intubation was 108.43 ± 6.26 bpm, 112.20 ± 8.88 mmHg and after 3 minutes of intubation was 76.20 ± 4.16 bpm, 88.20 ± 3.93 respectively while in group II (1.0 µg/kg dexmedetomidine infusion), the mean HR and MAP before intubation 102.10 ± 10.20 bpm, 109.07 ± 8.35 mmHg and after 3 minutes of intubation was 85.97 ± 3.26 bpm, 97.90 ± 5.74 mmHg respectively. Conclusion: Higher dose of dexmedetomidine (1.0 ug/kg) significantly attenuates hemodynamic response on endotracheal intubation as compare to lower dose (0.5 µg/kg).https://ojs.lifenscience.org/index.php/life-and-science/article/view/334dexmedetomidine, endotracheal intubation, heart rate, hemodynamic, mean arterial pressure. |
| spellingShingle | Tasneem Alam Sanum Kashif Khalid Mehmood Umair . Akhtar Hussain Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal Intubation Life and Science dexmedetomidine, endotracheal intubation, heart rate, hemodynamic, mean arterial pressure. |
| title | Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal Intubation |
| title_full | Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal Intubation |
| title_fullStr | Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal Intubation |
| title_full_unstemmed | Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal Intubation |
| title_short | Comparison of Mean Hemodynamic Change with Different Doses of Intravenous Dexmedetomidine on Endotracheal Intubation |
| title_sort | comparison of mean hemodynamic change with different doses of intravenous dexmedetomidine on endotracheal intubation |
| topic | dexmedetomidine, endotracheal intubation, heart rate, hemodynamic, mean arterial pressure. |
| url | https://ojs.lifenscience.org/index.php/life-and-science/article/view/334 |
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