Immunoelectron microscopy and biochemical studies using three anti-tau antibodies in human brains: associations between pTau and ribosomes

Immunoelectron microscopy and biochemical studies using three anti-tau antibodies in human brains: associations between pTau and ribosomes

Abstract The hallmark neuropathological lesions of Alzheimer’s disease (AD) are extracellular amyloid-beta (Aβ) plaque deposits and intracellular Tau neurofibrillary tangles (NFTs). Identifying the intracellular localization of early pathologic changes can enhance our understanding of disease mechan...

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Bibliographic Details
Main Authors: Douglas Price, Jillian Cramer, Colin B. Rogers, Paresh Prajapati, Yamaan Shakhashiro, Peter T. Nelson, Wang-Xia Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Human brain
Tau phosphorylation
Alzheimer’s disease
ImmunoEM
Serial sections
Subcellular fractionation
Online Access:https://doi.org/10.1186/s40478-025-02072-2
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