Longitudinal evaluation of circulating tumor DNA in patients undergoing neoadjuvant therapy for early breast cancer using a tumor-informed assay

Longitudinal evaluation of circulating tumor DNA in patients undergoing neoadjuvant therapy for early breast cancer using a tumor-informed assay

Abstract Circulating tumor DNA (ctDNA) is an emerging biomarker for the treatment of early breast cancer (EBC). We sought to evaluate a highly sensitive tumor-informed ctDNA assay in a real-world cohort of patients receiving neoadjuvant therapy (NAT) to assess clinical validity and explore prognosti...

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Bibliographic Details
Main Authors: Mitchell J. Elliott, Philippe Echelard, Christodoulos Pipinikas, Sasha Main, Jesús Fuentes Antrás, Aaron Dou, Zachary Veitch, Eitan Amir, Michelle B. Nadler, Nicholas Meti, Eshetu Atenafu, Elizabeth Shah, Celeste Yu, Nathan Campbell, Robert Ventura, Lillian L. Siu, Philippe L. Bedard, Hal K. Berman, David W. Cescon
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56658-4
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