Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies
Myocardial infarction (MI), which is characterized by high morbidity and mortality, is a serious threat to human life and health, and timely reperfusion therapy to save ischemic myocardium is currently the most effective intervention. Although reperfusion therapy effectively restores coronary blood...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558484/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850148570069467136 |
|---|---|
| author | Xiaoyu Xuan Jilin Fan Jingyi Zhang Ming Ren Limin Feng Limin Feng |
| author_facet | Xiaoyu Xuan Jilin Fan Jingyi Zhang Ming Ren Limin Feng Limin Feng |
| author_sort | Xiaoyu Xuan |
| collection | DOAJ |
| description | Myocardial infarction (MI), which is characterized by high morbidity and mortality, is a serious threat to human life and health, and timely reperfusion therapy to save ischemic myocardium is currently the most effective intervention. Although reperfusion therapy effectively restores coronary blood flow and maximally limits the infarct size, it triggers additional cell death and tissue damage, which is known as myocardial ischemia/reperfusion injury (MIRI). Multiple immune cells are present in the reperfusion area, executing specific functions and engaging in crosstalk during diverse stages, constituting a complex immune microenvironment involved in tissue repair and regeneration after MIRI. Immunotherapy brings new hope for treating ischemic heart disease by modulating the immune microenvironment. In this paper, we explore the regulatory roles of various immune cells during MIRI and the close relationship between different cell deaths and the immune microenvironment. In addition, we present the current status of research on targeting the immune system to intervene in MIRI, with the expectation of providing a basis for achieving clinical translation. |
| format | Article |
| id | doaj-art-3833a5ed64a846d28aab7d582fa39efd |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3833a5ed64a846d28aab7d582fa39efd2025-08-20T02:27:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15584841558484Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategiesXiaoyu Xuan0Jilin Fan1Jingyi Zhang2Ming Ren3Limin Feng4Limin Feng5College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Rehabilitation, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, ChinaDepartment of Traditional Chinese Medicine, The Second Affiliated Hospital of Shandong First Medical University, Shandong, Taian, ChinaBaokang Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaThe Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaTianjin Binhai New Area Traditional Chinese Medicine Hospital, Tianjin, ChinaMyocardial infarction (MI), which is characterized by high morbidity and mortality, is a serious threat to human life and health, and timely reperfusion therapy to save ischemic myocardium is currently the most effective intervention. Although reperfusion therapy effectively restores coronary blood flow and maximally limits the infarct size, it triggers additional cell death and tissue damage, which is known as myocardial ischemia/reperfusion injury (MIRI). Multiple immune cells are present in the reperfusion area, executing specific functions and engaging in crosstalk during diverse stages, constituting a complex immune microenvironment involved in tissue repair and regeneration after MIRI. Immunotherapy brings new hope for treating ischemic heart disease by modulating the immune microenvironment. In this paper, we explore the regulatory roles of various immune cells during MIRI and the close relationship between different cell deaths and the immune microenvironment. In addition, we present the current status of research on targeting the immune system to intervene in MIRI, with the expectation of providing a basis for achieving clinical translation.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558484/fullmyocardial ischemia/reperfusion injurymyocardial infarctionimmune cellcell deathimmunotherapy |
| spellingShingle | Xiaoyu Xuan Jilin Fan Jingyi Zhang Ming Ren Limin Feng Limin Feng Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies Frontiers in Immunology myocardial ischemia/reperfusion injury myocardial infarction immune cell cell death immunotherapy |
| title | Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies |
| title_full | Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies |
| title_fullStr | Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies |
| title_full_unstemmed | Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies |
| title_short | Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies |
| title_sort | immune in myocardial ischemia reperfusion injury potential mechanisms and therapeutic strategies |
| topic | myocardial ischemia/reperfusion injury myocardial infarction immune cell cell death immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558484/full |
| work_keys_str_mv | AT xiaoyuxuan immuneinmyocardialischemiareperfusioninjurypotentialmechanismsandtherapeuticstrategies AT jilinfan immuneinmyocardialischemiareperfusioninjurypotentialmechanismsandtherapeuticstrategies AT jingyizhang immuneinmyocardialischemiareperfusioninjurypotentialmechanismsandtherapeuticstrategies AT mingren immuneinmyocardialischemiareperfusioninjurypotentialmechanismsandtherapeuticstrategies AT liminfeng immuneinmyocardialischemiareperfusioninjurypotentialmechanismsandtherapeuticstrategies AT liminfeng immuneinmyocardialischemiareperfusioninjurypotentialmechanismsandtherapeuticstrategies |