The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats [version 3; peer review: 1 approved, 2 approved with reservations]
Background: When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. Hypofunctional teeth would have less VEGF expression and decreased heparan sulfate proteoglycan production during orthodontic tooth movement. This study aimed to determine...
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F1000 Research Ltd
2022-06-01
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| author | Adibah Maulani Darmawan Sutantyo Cendrawasih Andusyana Farmasyanti |
| author_facet | Adibah Maulani Darmawan Sutantyo Cendrawasih Andusyana Farmasyanti |
| author_sort | Adibah Maulani |
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| description | Background: When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. Hypofunctional teeth would have less VEGF expression and decreased heparan sulfate proteoglycan production during orthodontic tooth movement. This study aimed to determine the number of osteoblasts in the tension side and the number of osteoclasts in the pressure side of the hypofunctional teeth during orthodontic tooth movement. Method: 18 male Wistar rats were given a palatal coil spring application on the maxillary incisors. Rats were divided into two groups, the orthodontic group with normal occlusion (NO) and hypofunctional occlusion (HO). The number of osteoblasts on the tension side and osteoclasts on the pressure side on days zero (D0), five (D5), and 10 (D10) were tested with two-way ANOVA. Observations were made by hematoxylin eosin staining. Result: The results showed that the number of osteoblasts on the tension side of the HO group was the same at the NO group (p> 0.05). The number of osteoblasts on the tension side in the NO and HO groups at D5 was the same at D10 (p = 0.99), but significantly higher (p = 0.002), than D0. The number of osteoclasts on the pressure side in the HO group was significantly lower than the NO group (p <0.05). The number of osteoclasts in the NO D5 group was significantly higher than the other groups (p <0.05). Conclusions: The number of osteoblasts on the tension side was not affected by the hypofunctional state but decreased the number of osteoclasts on the pressure side during orthodontic tooth movement. |
| format | Article |
| id | doaj-art-3831c43107354ca996e5a04bfeda1909 |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2022-06-01 |
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| spelling | doaj-art-3831c43107354ca996e5a04bfeda19092024-11-20T01:00:00ZengF1000 Research LtdF1000Research2046-14022022-06-0110134578The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats [version 3; peer review: 1 approved, 2 approved with reservations]Adibah Maulani0https://orcid.org/0000-0002-2305-1447Darmawan Sutantyo1Cendrawasih Andusyana Farmasyanti2https://orcid.org/0000-0001-6556-8404Orthodontic Postgraduate Education Program, Faculty of Dentistry, Gadjah Mada University, Sleman, Yogyakarta, 55281, IndonesiaDepartment of Orthodontics, Faculty of Dentistry, Gadjah Mada University, Sleman, Yogyakarta, 55281, IndonesiaDepartment of Orthodontics, Faculty of Dentistry, Gadjah Mada University, Sleman, Yogyakarta, 55281, IndonesiaBackground: When moved orthodontically, hypofunctional teeth will have a decreased tooth movement rate compared to normal teeth. Hypofunctional teeth would have less VEGF expression and decreased heparan sulfate proteoglycan production during orthodontic tooth movement. This study aimed to determine the number of osteoblasts in the tension side and the number of osteoclasts in the pressure side of the hypofunctional teeth during orthodontic tooth movement. Method: 18 male Wistar rats were given a palatal coil spring application on the maxillary incisors. Rats were divided into two groups, the orthodontic group with normal occlusion (NO) and hypofunctional occlusion (HO). The number of osteoblasts on the tension side and osteoclasts on the pressure side on days zero (D0), five (D5), and 10 (D10) were tested with two-way ANOVA. Observations were made by hematoxylin eosin staining. Result: The results showed that the number of osteoblasts on the tension side of the HO group was the same at the NO group (p> 0.05). The number of osteoblasts on the tension side in the NO and HO groups at D5 was the same at D10 (p = 0.99), but significantly higher (p = 0.002), than D0. The number of osteoclasts on the pressure side in the HO group was significantly lower than the NO group (p <0.05). The number of osteoclasts in the NO D5 group was significantly higher than the other groups (p <0.05). Conclusions: The number of osteoblasts on the tension side was not affected by the hypofunctional state but decreased the number of osteoclasts on the pressure side during orthodontic tooth movement.https://f1000research.com/articles/10-541/v3Tooth movement osteoblast osteoclast hypofunctionaleng |
| spellingShingle | Adibah Maulani Darmawan Sutantyo Cendrawasih Andusyana Farmasyanti The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats [version 3; peer review: 1 approved, 2 approved with reservations] F1000Research Tooth movement osteoblast osteoclast hypofunctional eng |
| title | The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats [version 3; peer review: 1 approved, 2 approved with reservations] |
| title_full | The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats [version 3; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats [version 3; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats [version 3; peer review: 1 approved, 2 approved with reservations] |
| title_short | The number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats [version 3; peer review: 1 approved, 2 approved with reservations] |
| title_sort | number of osteoblasts and osteoclasts in hypofunctional teeth during orthodontic tooth movement in rats version 3 peer review 1 approved 2 approved with reservations |
| topic | Tooth movement osteoblast osteoclast hypofunctional eng |
| url | https://f1000research.com/articles/10-541/v3 |
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