PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease
Objectives The effect of air pollution on the prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) remains poorly understood. We aimed to evaluate the effect of long-term exposure to particulate matter with an aerodynamic diameter of ≤10 µm (PM10) and nitrogen dioxide (NO2...
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BMJ Publishing Group
2024-02-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/10/1/e003680.full |
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| author | Jin Woo Song Sun-Young Kim Hee-Young Yoon Soo Han Kim |
| author_facet | Jin Woo Song Sun-Young Kim Hee-Young Yoon Soo Han Kim |
| author_sort | Jin Woo Song |
| collection | DOAJ |
| description | Objectives The effect of air pollution on the prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) remains poorly understood. We aimed to evaluate the effect of long-term exposure to particulate matter with an aerodynamic diameter of ≤10 µm (PM10) and nitrogen dioxide (NO2) on mortality in patients with RA-ILD.Methods We included 309 patients (mean age, 61.7 years; male, 44.3%) with RA-ILD. Individual-level long-term exposures to PM10 and NO2 at their residential addresses were estimated using a national-scale exposure prediction model. The effect of the two air pollutants on mortality was estimated using a Cox-proportional hazards model adjusted for individual-level and area-level characteristics.Results The median follow-up period was 4.8 years, and 40.8% of patients died or underwent lung transplantation. The annual average concentrations of PM10 and NO2 were 56.3 μg/m3 and 22.4 ppb, respectively. When air pollutant levels were stratified by quartiles, no association was observed between air pollutant concentration and mortality in patients with RA-ILD. However, when stratified by two groups (high exposure (top 25th percentile) vs low exposure (bottom 75th percentile)), we observed a significant association between high PM10 exposure and mortality (HR 1.68; 95% CI 1.11 to 2.52; p=0.013) but no association between NO2 exposure and mortality. In the subgroup analyses, the effect of high PM10 exposure on mortality was significant in patients aged <65 years (HR 1.98; 95% CI 1.02 to 3.85; p=0.045).Conclusions Our results indicated that high PM10 exposure may be associated with mortality in patients with RA-ILD. |
| format | Article |
| id | doaj-art-382f7fb7f1e945c2be63dbdabd6593db |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-382f7fb7f1e945c2be63dbdabd6593db2025-08-20T03:48:31ZengBMJ Publishing GroupRMD Open2056-59332024-02-0110110.1136/rmdopen-2023-003680PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung diseaseJin Woo Song0Sun-Young Kim1Hee-Young Yoon2Soo Han Kim3Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Korea (the Republic of)Department of Cancer AI & Digital Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South KoreaDivision of Allergy and Respiratory Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea (the Republic of)Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaObjectives The effect of air pollution on the prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) remains poorly understood. We aimed to evaluate the effect of long-term exposure to particulate matter with an aerodynamic diameter of ≤10 µm (PM10) and nitrogen dioxide (NO2) on mortality in patients with RA-ILD.Methods We included 309 patients (mean age, 61.7 years; male, 44.3%) with RA-ILD. Individual-level long-term exposures to PM10 and NO2 at their residential addresses were estimated using a national-scale exposure prediction model. The effect of the two air pollutants on mortality was estimated using a Cox-proportional hazards model adjusted for individual-level and area-level characteristics.Results The median follow-up period was 4.8 years, and 40.8% of patients died or underwent lung transplantation. The annual average concentrations of PM10 and NO2 were 56.3 μg/m3 and 22.4 ppb, respectively. When air pollutant levels were stratified by quartiles, no association was observed between air pollutant concentration and mortality in patients with RA-ILD. However, when stratified by two groups (high exposure (top 25th percentile) vs low exposure (bottom 75th percentile)), we observed a significant association between high PM10 exposure and mortality (HR 1.68; 95% CI 1.11 to 2.52; p=0.013) but no association between NO2 exposure and mortality. In the subgroup analyses, the effect of high PM10 exposure on mortality was significant in patients aged <65 years (HR 1.98; 95% CI 1.02 to 3.85; p=0.045).Conclusions Our results indicated that high PM10 exposure may be associated with mortality in patients with RA-ILD.https://rmdopen.bmj.com/content/10/1/e003680.full |
| spellingShingle | Jin Woo Song Sun-Young Kim Hee-Young Yoon Soo Han Kim PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease RMD Open |
| title | PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease |
| title_full | PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease |
| title_fullStr | PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease |
| title_full_unstemmed | PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease |
| title_short | PM10 increases mortality risk in rheumatoid arthritis-associated interstitial lung disease |
| title_sort | pm10 increases mortality risk in rheumatoid arthritis associated interstitial lung disease |
| url | https://rmdopen.bmj.com/content/10/1/e003680.full |
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