Durable response to nivolumab in combination with regional hyperthermia in a patient with PD-L1-negative metastatic head and neck squamous cell carcinoma

Durable response to nivolumab in combination with regional hyperthermia in a patient with PD-L1-negative metastatic head and neck squamous cell carcinoma

Abstract We report a long-lasting response to the immune checkpoint inhibitor nivolumab in combination with regional hyperthermia (RHT) in a patient with recurrent metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) and negative programmed death ligand 1 (PD-L1) expression. Treatment was well t...

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Bibliographic Details
Main Authors: Luc M. Berclaz, Anton Burkhard-Meier, Axel Lechner, Michael Völkl, Sinan E. Güler, Sultan Abdel-Rahman, Sina Mansoorian, Wolfgang G. Kunz, Thomas Knösel, Martin Canis, Michael von Bergwelt-Baildon, Rolf D. Issels, Dorit Di Gioia, Lars H. Lindner
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Immunotherapy
Immune checkpoint inhibitors
Head and neck cancer
Regional hyperthermia
Online Access:https://doi.org/10.1007/s00262-025-04029-9
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