Dose-dependent dual effects of HDAC inhibitors on glial inflammatory response

Dose-dependent dual effects of HDAC inhibitors on glial inflammatory response

Abstract Neuroinflammation is defined as a process that includes cellular responses designed to protect the central nervous system from external influences, and it initiates in cases of extreme deviations from homeostasis. While it serves a protective role, excessive immune activation can lead to th...

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Bibliographic Details
Main Authors: Samantha Mancino, Mariaserena Boraso, Andrea Galmozzi, Melania Maria Serafini, Emma De Fabiani, Maurizio Crestani, Barbara Viviani
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Neuroinflammation
Histone deacetylase inhibition
Trichostatin A
Suberoylanilide hydroxamic acid
MS-275
MC1568
Online Access:https://doi.org/10.1038/s41598-025-96241-x
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