PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C‐Myc Feedback Loop

PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C‐Myc Feedback Loop

ABSTRACT The oncogenic role and underlying mechanism of PRMT5 in pancreatic ductal adenocarcinoma (PAAD) remained to be elucidated. In this study, we aimed to investigate the oncogenic role, underlying molecular mechanisms, and potential therapeutic value of PRMT5 in PAAD. PRMT5 was significantly up...

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Bibliographic Details
Main Authors: Fan Yang, Ping Song, Zhaofeng Xiao, Renyi Su, Xin Fang, Yichao Wu, Xiao Xu, Kai Wang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:MedComm
Subjects:
pancreatic cancer
PRMT5
c‐Myc
positive feedback loop
proliferation
therapeutic targets
Online Access:https://doi.org/10.1002/mco2.70150
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