M2 macrophage infusion ameliorates diabetic glomerulopathy via the JAK2/STAT3 pathway in db/db mice

M2 macrophage infusion ameliorates diabetic glomerulopathy via the JAK2/STAT3 pathway in db/db mice

Objectives: To explore the therapeutic effects of M2 macrophages in diabetic nephropathy (DN) and their mechanism.Methods: We infused M2 macrophages stimulated with IL-4 into 10-week-old db/db mice once a week for 4 weeks through the tail vein as M2 group. Then we investigated the role of M2 macroph...

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Bibliographic Details
Main Authors: Yulin Gu, Songyan Yu, Weijun Gu, Bing Li, Jing Xue, Jiejie Liu, Qi Zhang, Yaqi Yin, Haixia Zhang, Qinghua Guo, Mingxia Yuan, Zhaohui Lyu, Yiming Mu, Yu Cheng
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Diabetic complication
diabetic nephropathy
M2 macrophages
inflammation
JAK2/STAT3 pathway
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2378210
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