Safety and efficacy of a feed additive consisting of l‐valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.)
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l‐valine produced by fermentation using a non‐genetically modified strain of Corynebacterium glutamicum (CGMCC 18932). l‐Valine is intended to be used in feed and w...
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Wiley
2023-07-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2023.8104 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lieve Herman Montserrat Anguita Jordi Tarrés‐Call Joana P Firmino |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lieve Herman Montserrat Anguita Jordi Tarrés‐Call Joana P Firmino |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l‐valine produced by fermentation using a non‐genetically modified strain of Corynebacterium glutamicum (CGMCC 18932). l‐Valine is intended to be used in feed and water for drinking as a nutritional additive, functional group amino acids, their salts and analogues, for all animal species and categories. The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concluded that l‐valine produced by C. glutamicum CGMCC 18932 is considered safe for the target species when supplemented to the diet in appropriate amounts according to the nutritional needs of the target species. The use of l‐valine produced using C. glutamicum CGMCC 18932 in animal nutrition is considered safe for the consumer and for the environment. No conclusion could be drawn on the potential of l‐valine produced using C. glutamicum CGMCC 18932 to be irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The FEEDAP Panel concluded that the l‐valine produced by fermentation using C. glutamicum CGMCC 18932 is an efficacious source of the essential amino acid l‐valine for non‐ruminant nutrition. To be as efficacious in ruminants as in non‐ruminants, supplemental l‐valine requires protection against ruminal degradation. The FEEDAP Panel expressed concerns on the use of amino acids in water for drinking for hygienic reasons. |
| format | Article |
| id | doaj-art-381f9e7521c04bdfbbea3ed9036fbf22 |
| institution | OA Journals |
| issn | 1831-4732 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-381f9e7521c04bdfbbea3ed9036fbf222025-08-20T02:12:57ZengWileyEFSA Journal1831-47322023-07-01217n/an/a10.2903/j.efsa.2023.8104Safety and efficacy of a feed additive consisting of l‐valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenMojca DurjavaBirgit DusemundMaryline KoubaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosYolanda SanzRoberto Edoardo VillaRuud WoutersenLieve HermanMontserrat AnguitaJordi Tarrés‐CallJoana P FirminoAbstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l‐valine produced by fermentation using a non‐genetically modified strain of Corynebacterium glutamicum (CGMCC 18932). l‐Valine is intended to be used in feed and water for drinking as a nutritional additive, functional group amino acids, their salts and analogues, for all animal species and categories. The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concluded that l‐valine produced by C. glutamicum CGMCC 18932 is considered safe for the target species when supplemented to the diet in appropriate amounts according to the nutritional needs of the target species. The use of l‐valine produced using C. glutamicum CGMCC 18932 in animal nutrition is considered safe for the consumer and for the environment. No conclusion could be drawn on the potential of l‐valine produced using C. glutamicum CGMCC 18932 to be irritant to the skin or eyes, or a dermal sensitiser due to the lack of data. The FEEDAP Panel concluded that the l‐valine produced by fermentation using C. glutamicum CGMCC 18932 is an efficacious source of the essential amino acid l‐valine for non‐ruminant nutrition. To be as efficacious in ruminants as in non‐ruminants, supplemental l‐valine requires protection against ruminal degradation. The FEEDAP Panel expressed concerns on the use of amino acids in water for drinking for hygienic reasons.https://doi.org/10.2903/j.efsa.2023.8104nutritional additivesaminoacidstheir salts and analoguesl‐valineCorynebacterium glutamicumsafety |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lieve Herman Montserrat Anguita Jordi Tarrés‐Call Joana P Firmino Safety and efficacy of a feed additive consisting of l‐valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.) EFSA Journal nutritional additives aminoacids their salts and analogues l‐valine Corynebacterium glutamicum safety |
| title | Safety and efficacy of a feed additive consisting of l‐valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.) |
| title_full | Safety and efficacy of a feed additive consisting of l‐valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.) |
| title_fullStr | Safety and efficacy of a feed additive consisting of l‐valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.) |
| title_full_unstemmed | Safety and efficacy of a feed additive consisting of l‐valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.) |
| title_short | Safety and efficacy of a feed additive consisting of l‐valine produced by Corynebacterium glutamicum CGMCC 18932 for all animal species (Xinjiang Fufeng Biotechnologies Co., Ltd.) |
| title_sort | safety and efficacy of a feed additive consisting of l valine produced by corynebacterium glutamicum cgmcc 18932 for all animal species xinjiang fufeng biotechnologies co ltd |
| topic | nutritional additives aminoacids their salts and analogues l‐valine Corynebacterium glutamicum safety |
| url | https://doi.org/10.2903/j.efsa.2023.8104 |
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