Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases
As the earliest studied epigenetic modification, acetylation has been explored a lot through the years. While bone tissue acts as an indispensable part of body, researches aimed at the relationship between the bone and acetylation became necessary. Some environmental factors like diet may affect the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/8043346 |
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| author | Qinglu Tian Shiqi Gao Xuedong Zhou Liwei Zheng Yachuan Zhou |
| author_facet | Qinglu Tian Shiqi Gao Xuedong Zhou Liwei Zheng Yachuan Zhou |
| author_sort | Qinglu Tian |
| collection | DOAJ |
| description | As the earliest studied epigenetic modification, acetylation has been explored a lot through the years. While bone tissue acts as an indispensable part of body, researches aimed at the relationship between the bone and acetylation became necessary. Some environmental factors like diet may affect the metabolism status that some metabolites especially nicotinamide adenine dinucleotide (NAD) were found able to regulate intracellular histone acetylation in bone metabolism. This review focuses on representing the interaction among acetylation, metabolism, and the bone. The results showed that acetylation connects a lot with bone metabolism, while the explorations about related metabolites like acetyl-CoA or different environmental exposures are still limited. Some acetylation-related therapy methods of bone diseases based on metabolic regulation or epigenetic enzymes were also reviewed. |
| format | Article |
| id | doaj-art-381a8eb537c14687b26658faeac0a944 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-381a8eb537c14687b26658faeac0a9442025-02-03T01:05:32ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/80433468043346Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related DiseasesQinglu Tian0Shiqi Gao1Xuedong Zhou2Liwei Zheng3Yachuan Zhou4State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, ChinaAs the earliest studied epigenetic modification, acetylation has been explored a lot through the years. While bone tissue acts as an indispensable part of body, researches aimed at the relationship between the bone and acetylation became necessary. Some environmental factors like diet may affect the metabolism status that some metabolites especially nicotinamide adenine dinucleotide (NAD) were found able to regulate intracellular histone acetylation in bone metabolism. This review focuses on representing the interaction among acetylation, metabolism, and the bone. The results showed that acetylation connects a lot with bone metabolism, while the explorations about related metabolites like acetyl-CoA or different environmental exposures are still limited. Some acetylation-related therapy methods of bone diseases based on metabolic regulation or epigenetic enzymes were also reviewed.http://dx.doi.org/10.1155/2021/8043346 |
| spellingShingle | Qinglu Tian Shiqi Gao Xuedong Zhou Liwei Zheng Yachuan Zhou Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases Stem Cells International |
| title | Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases |
| title_full | Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases |
| title_fullStr | Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases |
| title_full_unstemmed | Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases |
| title_short | Histone Acetylation in the Epigenetic Regulation of Bone Metabolism and Related Diseases |
| title_sort | histone acetylation in the epigenetic regulation of bone metabolism and related diseases |
| url | http://dx.doi.org/10.1155/2021/8043346 |
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