Internalized polystyrene nanoplastics trigger testicular damage and promote ferroptosis via CISD1 downregulation in mouse spermatocyte

Internalized polystyrene nanoplastics trigger testicular damage and promote ferroptosis via CISD1 downregulation in mouse spermatocyte

Abstract Background There is a growing body of research regarding the potential reproductive toxicity of microplastics and nanoplastics. However, the underlying mechanisms by which nanoplastics exposure adversely affects the testes remain poorly understood. Our study aims to clarify the relationship...

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Bibliographic Details
Main Authors: Jing Lv, Guangyu Liu, Ziqi Wang, Jueshun Zhang, Yuanyou Li, Yifan Wang, Ning Liu, Shayakhmetova Altyn, Zhongliang Jiang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Polystyrene nanoplastics
Testes
Spermatocyte
Ferritinophagy
CISD1
Online Access:https://doi.org/10.1186/s12951-025-03620-7
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