Age-independent association between high-sensitivity C-reactive protein and blood pressure in middle-aged adults
Background/Aim. There is growing evidence suggesting that high-sensitivity C-reactive protein (hs-CRP) is a reliable biomarker in patients with hypertension. While the relation-ship between hypertension and age is well established, the connection between hs-CRP and age remains unclear. The aim of th...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2023-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300042Z.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849699628151209984 |
|---|---|
| author | Zhao Huijun Lu Yiwen Niu Junjie Bian Hong Kuang Xingya |
| author_facet | Zhao Huijun Lu Yiwen Niu Junjie Bian Hong Kuang Xingya |
| author_sort | Zhao Huijun |
| collection | DOAJ |
| description | Background/Aim. There is growing evidence suggesting that high-sensitivity C-reactive protein (hs-CRP) is a reliable biomarker in patients with hypertension. While the relation-ship between hypertension and age is well established, the connection between hs-CRP and age remains unclear. The aim of the study was to determine a relationship between hs-CRP and age, body mass index (BMI), and blood pressure in middle-aged people. Methods. This cross-sectional survey was conducted in Shanghai, China, and it included data from 1,677 healthy male participants aged 18 to 50 years and 1,127 healthy female participants aged 19 to 49 years recruited during routine health examinations. The hs-CRP, BMI, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded. Results. The participants were first separated into four age quartile groups, in which an increase in BMI, SBP, and DBP was observed but not in hs-CRP. Afterward, the participants were divided into four hs-CRP quartile groups, in which an increase in BMI, SBP, and DBP was noted, but not in age. Finally, using Pearson correlation, positive correlations were found between hs-CRP, BMI, SBP, and DBP, but no correlation was discovered between age and hs-CRP. Conclusion. The authors showed that age is likely a confounding factor that correlates with SBP, DBP, and BMI, but it does not directly correlate with hs-CRP. |
| format | Article |
| id | doaj-art-3816a2dbfbc14162b1d65cba334a0bc8 |
| institution | DOAJ |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-3816a2dbfbc14162b1d65cba334a0bc82025-08-20T03:18:32ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202023-01-01801191592010.2298/VSP221130042Z0042-84502300042ZAge-independent association between high-sensitivity C-reactive protein and blood pressure in middle-aged adultsZhao Huijun0Lu Yiwen1Niu Junjie2Bian Hong3Kuang Xingya4Tongji University Yangpu Hospital, Department of Occupational Medicine, Shanghai, ChinaTongji University Yangpu Hospital, Department of Occupational Medicine, Shanghai, ChinaTongji University Yangpu Hospital, Department of Occupational Medicine, Shanghai, ChinaTongji University Yangpu Hospital, Department of Occupational Medicine, Shanghai, ChinaTongji University Yangpu Hospital, Department of Occupational Medicine, Shanghai, ChinaBackground/Aim. There is growing evidence suggesting that high-sensitivity C-reactive protein (hs-CRP) is a reliable biomarker in patients with hypertension. While the relation-ship between hypertension and age is well established, the connection between hs-CRP and age remains unclear. The aim of the study was to determine a relationship between hs-CRP and age, body mass index (BMI), and blood pressure in middle-aged people. Methods. This cross-sectional survey was conducted in Shanghai, China, and it included data from 1,677 healthy male participants aged 18 to 50 years and 1,127 healthy female participants aged 19 to 49 years recruited during routine health examinations. The hs-CRP, BMI, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were recorded. Results. The participants were first separated into four age quartile groups, in which an increase in BMI, SBP, and DBP was observed but not in hs-CRP. Afterward, the participants were divided into four hs-CRP quartile groups, in which an increase in BMI, SBP, and DBP was noted, but not in age. Finally, using Pearson correlation, positive correlations were found between hs-CRP, BMI, SBP, and DBP, but no correlation was discovered between age and hs-CRP. Conclusion. The authors showed that age is likely a confounding factor that correlates with SBP, DBP, and BMI, but it does not directly correlate with hs-CRP.https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300042Z.pdfage factorsbiomarkersblood pressurebody mass indexc-reactive protein |
| spellingShingle | Zhao Huijun Lu Yiwen Niu Junjie Bian Hong Kuang Xingya Age-independent association between high-sensitivity C-reactive protein and blood pressure in middle-aged adults Vojnosanitetski Pregled age factors biomarkers blood pressure body mass index c-reactive protein |
| title | Age-independent association between high-sensitivity C-reactive protein and blood pressure in middle-aged adults |
| title_full | Age-independent association between high-sensitivity C-reactive protein and blood pressure in middle-aged adults |
| title_fullStr | Age-independent association between high-sensitivity C-reactive protein and blood pressure in middle-aged adults |
| title_full_unstemmed | Age-independent association between high-sensitivity C-reactive protein and blood pressure in middle-aged adults |
| title_short | Age-independent association between high-sensitivity C-reactive protein and blood pressure in middle-aged adults |
| title_sort | age independent association between high sensitivity c reactive protein and blood pressure in middle aged adults |
| topic | age factors biomarkers blood pressure body mass index c-reactive protein |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2023/0042-84502300042Z.pdf |
| work_keys_str_mv | AT zhaohuijun ageindependentassociationbetweenhighsensitivitycreactiveproteinandbloodpressureinmiddleagedadults AT luyiwen ageindependentassociationbetweenhighsensitivitycreactiveproteinandbloodpressureinmiddleagedadults AT niujunjie ageindependentassociationbetweenhighsensitivitycreactiveproteinandbloodpressureinmiddleagedadults AT bianhong ageindependentassociationbetweenhighsensitivitycreactiveproteinandbloodpressureinmiddleagedadults AT kuangxingya ageindependentassociationbetweenhighsensitivitycreactiveproteinandbloodpressureinmiddleagedadults |