Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposure
Accidental oil spills significantly threaten marine ecosystems and fisheries, impacting biodiversity and ecological health. This study examines the downstream transcriptomic responses of Atlantic halibut larvae exposed to crude oil during organogenesis. Findings show concentration-dependent transcri...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325004877 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849713672568438784 |
|---|---|
| author | Elin Sørhus Kai K. Lie Sonnich Meier Tomasz Furmanek Birgitta Norberg Prescilla Perrichon |
| author_facet | Elin Sørhus Kai K. Lie Sonnich Meier Tomasz Furmanek Birgitta Norberg Prescilla Perrichon |
| author_sort | Elin Sørhus |
| collection | DOAJ |
| description | Accidental oil spills significantly threaten marine ecosystems and fisheries, impacting biodiversity and ecological health. This study examines the downstream transcriptomic responses of Atlantic halibut larvae exposed to crude oil during organogenesis. Findings show concentration-dependent transcriptional abnormalities. Pathway analysis at 10 days post-hatch (dph), 11 days after cessation of oil exposure, indicates downregulation of inflammatory and reparative pathways. By 18 dph, tissue-specific analyses reveal activation of these pathways, especially in head tissues, alongside upregulation of neuronal signaling pathways. This highlights the complex relationship between oil exposure and transcriptional responses, emphasizing recovery mechanisms represented by regulation of inflammatory, repair and wound healing pathways following oil exposure. The activation of repair pathways in surviving larvae suggests compensatory processes to address oil-induced damage. These novel insights enhance understanding of the molecular mechanisms of oil toxicity and the lasting effects on marine organisms. |
| format | Article |
| id | doaj-art-38122fc762cd4cc6818eec4dc55669b8 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-38122fc762cd4cc6818eec4dc55669b82025-08-20T03:13:54ZengElsevierEcotoxicology and Environmental Safety0147-65132025-05-0129611815110.1016/j.ecoenv.2025.118151Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposureElin Sørhus0Kai K. Lie1Sonnich Meier2Tomasz Furmanek3Birgitta Norberg4Prescilla Perrichon5Institute of Marine Research, Nordnesgaten 50, Bergen, Norway; Corresponding author.Institute of Marine Research, Nordnesgaten 50, Bergen, NorwayInstitute of Marine Research, Nordnesgaten 50, Bergen, NorwayInstitute of Marine Research, Nordnesgaten 50, Bergen, NorwayInstitute of Marine Research, Austevoll Research station, Sauganeset 16, Storebø, NorwayInstitute of Marine Research, Austevoll Research station, Sauganeset 16, Storebø, NorwayAccidental oil spills significantly threaten marine ecosystems and fisheries, impacting biodiversity and ecological health. This study examines the downstream transcriptomic responses of Atlantic halibut larvae exposed to crude oil during organogenesis. Findings show concentration-dependent transcriptional abnormalities. Pathway analysis at 10 days post-hatch (dph), 11 days after cessation of oil exposure, indicates downregulation of inflammatory and reparative pathways. By 18 dph, tissue-specific analyses reveal activation of these pathways, especially in head tissues, alongside upregulation of neuronal signaling pathways. This highlights the complex relationship between oil exposure and transcriptional responses, emphasizing recovery mechanisms represented by regulation of inflammatory, repair and wound healing pathways following oil exposure. The activation of repair pathways in surviving larvae suggests compensatory processes to address oil-induced damage. These novel insights enhance understanding of the molecular mechanisms of oil toxicity and the lasting effects on marine organisms.http://www.sciencedirect.com/science/article/pii/S0147651325004877Atlantic halibutCrude oil exposureTranscriptomicsOrganogenesisPathway analysisDownstream effects |
| spellingShingle | Elin Sørhus Kai K. Lie Sonnich Meier Tomasz Furmanek Birgitta Norberg Prescilla Perrichon Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposure Ecotoxicology and Environmental Safety Atlantic halibut Crude oil exposure Transcriptomics Organogenesis Pathway analysis Downstream effects |
| title | Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposure |
| title_full | Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposure |
| title_fullStr | Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposure |
| title_full_unstemmed | Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposure |
| title_short | Transcriptomics uncover inhibition of repair and wound healing pathways in Atlantic halibut (Hippoglossus hippoglossus) after crude oil exposure |
| title_sort | transcriptomics uncover inhibition of repair and wound healing pathways in atlantic halibut hippoglossus hippoglossus after crude oil exposure |
| topic | Atlantic halibut Crude oil exposure Transcriptomics Organogenesis Pathway analysis Downstream effects |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325004877 |
| work_keys_str_mv | AT elinsørhus transcriptomicsuncoverinhibitionofrepairandwoundhealingpathwaysinatlantichalibuthippoglossushippoglossusaftercrudeoilexposure AT kaiklie transcriptomicsuncoverinhibitionofrepairandwoundhealingpathwaysinatlantichalibuthippoglossushippoglossusaftercrudeoilexposure AT sonnichmeier transcriptomicsuncoverinhibitionofrepairandwoundhealingpathwaysinatlantichalibuthippoglossushippoglossusaftercrudeoilexposure AT tomaszfurmanek transcriptomicsuncoverinhibitionofrepairandwoundhealingpathwaysinatlantichalibuthippoglossushippoglossusaftercrudeoilexposure AT birgittanorberg transcriptomicsuncoverinhibitionofrepairandwoundhealingpathwaysinatlantichalibuthippoglossushippoglossusaftercrudeoilexposure AT prescillaperrichon transcriptomicsuncoverinhibitionofrepairandwoundhealingpathwaysinatlantichalibuthippoglossushippoglossusaftercrudeoilexposure |