Understanding Muscle Dysfunction in Chronic Fatigue Syndrome
Introduction. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating disorder of unknown aetiology, characterised by severe disabling fatigue in the absence of alternative diagnosis. Historically, there has been a tendency to draw psychological explanations for the origin of f...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2497348 |
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| author | Gina Rutherford Philip Manning Julia L. Newton |
| author_facet | Gina Rutherford Philip Manning Julia L. Newton |
| author_sort | Gina Rutherford |
| collection | DOAJ |
| description | Introduction. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating disorder of unknown aetiology, characterised by severe disabling fatigue in the absence of alternative diagnosis. Historically, there has been a tendency to draw psychological explanations for the origin of fatigue; however, this model is at odds with findings that fatigue and accompanying symptoms may be explained by central and peripheral pathophysiological mechanisms, including effects of the immune, oxidative, mitochondrial, and neuronal pathways. For example, patient descriptions of their fatigue regularly cite difficulty in maintaining muscle activity due to perceived lack of energy. This narrative review examined the literature for evidence of biochemical dysfunction in CFS/ME at the skeletal muscle level. Methods. Literature was examined following searches of PUB MED, MEDLINE, and Google Scholar, using key words such as CFS/ME, immune, autoimmune, mitochondria, muscle, and acidosis. Results. Studies show evidence for skeletal muscle biochemical abnormality in CFS/ME patients, particularly in relation to bioenergetic dysfunction. Discussion. Bioenergetic muscle dysfunction is evident in CFS/ME, with a tendency towards an overutilisation of the lactate dehydrogenase pathway following low-level exercise, in addition to slowed acid clearance after exercise. Potentially, these abnormalities may lead to the perception of severe fatigue in CFS/ME. |
| format | Article |
| id | doaj-art-381110d4152f417eb09875526a4cf122 |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-381110d4152f417eb09875526a4cf1222025-02-03T05:58:10ZengWileyJournal of Aging Research2090-22042090-22122016-01-01201610.1155/2016/24973482497348Understanding Muscle Dysfunction in Chronic Fatigue SyndromeGina Rutherford0Philip Manning1Julia L. Newton2Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UKInstitute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UKInstitute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UKIntroduction. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating disorder of unknown aetiology, characterised by severe disabling fatigue in the absence of alternative diagnosis. Historically, there has been a tendency to draw psychological explanations for the origin of fatigue; however, this model is at odds with findings that fatigue and accompanying symptoms may be explained by central and peripheral pathophysiological mechanisms, including effects of the immune, oxidative, mitochondrial, and neuronal pathways. For example, patient descriptions of their fatigue regularly cite difficulty in maintaining muscle activity due to perceived lack of energy. This narrative review examined the literature for evidence of biochemical dysfunction in CFS/ME at the skeletal muscle level. Methods. Literature was examined following searches of PUB MED, MEDLINE, and Google Scholar, using key words such as CFS/ME, immune, autoimmune, mitochondria, muscle, and acidosis. Results. Studies show evidence for skeletal muscle biochemical abnormality in CFS/ME patients, particularly in relation to bioenergetic dysfunction. Discussion. Bioenergetic muscle dysfunction is evident in CFS/ME, with a tendency towards an overutilisation of the lactate dehydrogenase pathway following low-level exercise, in addition to slowed acid clearance after exercise. Potentially, these abnormalities may lead to the perception of severe fatigue in CFS/ME.http://dx.doi.org/10.1155/2016/2497348 |
| spellingShingle | Gina Rutherford Philip Manning Julia L. Newton Understanding Muscle Dysfunction in Chronic Fatigue Syndrome Journal of Aging Research |
| title | Understanding Muscle Dysfunction in Chronic Fatigue Syndrome |
| title_full | Understanding Muscle Dysfunction in Chronic Fatigue Syndrome |
| title_fullStr | Understanding Muscle Dysfunction in Chronic Fatigue Syndrome |
| title_full_unstemmed | Understanding Muscle Dysfunction in Chronic Fatigue Syndrome |
| title_short | Understanding Muscle Dysfunction in Chronic Fatigue Syndrome |
| title_sort | understanding muscle dysfunction in chronic fatigue syndrome |
| url | http://dx.doi.org/10.1155/2016/2497348 |
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