Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease
Background. Vitamin A is essential for the preservation and integrity of the lung epithelium and exerts anti-inflammatory effects. Objective. Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD. Methods. We evaluated...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/862086 |
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| author | L. M. O. Caram R. A. F. Amaral R. Ferrari S. E. Tanni C. R. Correa S. A. R. Paiva I. Godoy |
| author_facet | L. M. O. Caram R. A. F. Amaral R. Ferrari S. E. Tanni C. R. Correa S. A. R. Paiva I. Godoy |
| author_sort | L. M. O. Caram |
| collection | DOAJ |
| description | Background. Vitamin A is essential for the preservation and integrity of the lung epithelium and exerts anti-inflammatory effects. Objective. Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD. Methods. We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7). Results. COPD exhibited lower serum vitamin A (1.8 (1.2–2.1) versus 2.1 (1.8–2.4) μmol/L, P<0.001) and lower vitamin A intake (636.9 (339.6–1349.6) versus 918.0 (592.1–1654.6) RAE, P=0.05) when compared with controls. Sputum concentration of vitamin A was not different between groups. Sputum vitamin A and neutrophils were negatively correlated (R2=-0.26; P=0.03). Smoking (0.197, P=0.042) exhibited positive association with serum vitamin A. COPD was associated with lower serum concentrations of vitamin A without relationship with the systemic inflammation. Conclusions. Serum concentration of vitamin A is negatively associated with the presence of COPD and positively associated with smoking status. Sputum retinol is quantifiable and is negatively influenced by neutrophils. Although COPD patients exhibited increased inflammation it was not associated with serum retinol. |
| format | Article |
| id | doaj-art-381066015f5948c0948af41c45342edb |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-381066015f5948c0948af41c45342edb2025-02-03T05:48:38ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/862086862086Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary DiseaseL. M. O. Caram0R. A. F. Amaral1R. Ferrari2S. E. Tanni3C. R. Correa4S. A. R. Paiva5I. Godoy6Department of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrazilDepartment of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrazilDepartment of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrazilDepartment of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrazilDepartment of Pathology, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrazilDepartment of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrazilDepartment of Internal Medicine, Pneumology Area, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu Campus, Distrito de Rubião Junior, s/n, 18618-970 Botucatu, SP, BrazilBackground. Vitamin A is essential for the preservation and integrity of the lung epithelium and exerts anti-inflammatory effects. Objective. Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD. Methods. We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7). Results. COPD exhibited lower serum vitamin A (1.8 (1.2–2.1) versus 2.1 (1.8–2.4) μmol/L, P<0.001) and lower vitamin A intake (636.9 (339.6–1349.6) versus 918.0 (592.1–1654.6) RAE, P=0.05) when compared with controls. Sputum concentration of vitamin A was not different between groups. Sputum vitamin A and neutrophils were negatively correlated (R2=-0.26; P=0.03). Smoking (0.197, P=0.042) exhibited positive association with serum vitamin A. COPD was associated with lower serum concentrations of vitamin A without relationship with the systemic inflammation. Conclusions. Serum concentration of vitamin A is negatively associated with the presence of COPD and positively associated with smoking status. Sputum retinol is quantifiable and is negatively influenced by neutrophils. Although COPD patients exhibited increased inflammation it was not associated with serum retinol.http://dx.doi.org/10.1155/2015/862086 |
| spellingShingle | L. M. O. Caram R. A. F. Amaral R. Ferrari S. E. Tanni C. R. Correa S. A. R. Paiva I. Godoy Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease Mediators of Inflammation |
| title | Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease |
| title_full | Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease |
| title_fullStr | Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease |
| title_short | Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease |
| title_sort | serum vitamin a and inflammatory markers in individuals with and without chronic obstructive pulmonary disease |
| url | http://dx.doi.org/10.1155/2015/862086 |
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