Mevalonate pathway-triggered phase transition of injectable hydrogel for cholesterol-downregulated therapy of osteoarthritis

Mevalonate pathway-triggered phase transition of injectable hydrogel for cholesterol-downregulated therapy of osteoarthritis

Dysregulation of mevalonate pathway, an essential metabolic route involving coenzyme A (CoASH) and cholesterol, contributes significantly to escalating cartilage degradation. Existing treatments rely on the simvastatin delivery via tunable sol-gel transition mechanisms of injectable hydrogel. Howeve...

Full description

Saved in:
Bibliographic Details
Main Authors: Akhmad Irhas Robby, Ee Hyun Kim, Kang Moo Huh, Eun-Jung Jin, Ki Dong Park, Sung Young Park
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-09-01
Series:Bioactive Materials
Subjects:
Osteoarthritis
Injectable hydrogel
Coenzyme A
Mevalonate pathway
Theragnostic
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2500283X
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items