Nonspecificity of adaptogenic effects of Ukrainian phytocompositions “Balm Truskavets’” and tea ATINE®
Background and aim. Recently, members of our informal group in independent experiments on rats, subject to acute stress, have demonstrated stress limiting and antioxidant effects of two Ukrainian Phytocompositions: “Balm Truskavets’” and herbal tea “ATINE”. Despite the qualitative similarity of ada...
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Kazimierz Wielki University
2025-08-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/64562 |
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| author | Igor Bombushkar Anatoliy Gozhenko Oksana Fihura Ivan Savytskyi Walery Zukow Igor Popovych |
| author_facet | Igor Bombushkar Anatoliy Gozhenko Oksana Fihura Ivan Savytskyi Walery Zukow Igor Popovych |
| author_sort | Igor Bombushkar |
| collection | DOAJ |
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Background and aim. Recently, members of our informal group in independent experiments on rats, subject to acute stress, have demonstrated stress limiting and antioxidant effects of two Ukrainian Phytocompositions: “Balm Truskavets’” and herbal tea “ATINE”. Despite the qualitative similarity of adaptogenic effects, their correct quantitative comparison is impossible in view of the different models of acute stress, and especially different batteries of tests. The aim of this study is to check the hypothesis of nonspecificity of adaptogenic effects of both phytocompositions by quantitative comparison of their synchronous effects on parameters of the neuro-endocrine-immune complex and the metabolism at rats.
Material and methods. The experiment carried up at 42 female rats Wistar line (weight mean 261±25g). 10 animals remained intact with free access to tap daily water, 10 formed a control group, whose members loaded intragastrically with same daily water (2,5 mL/200g) once for 14 days, while 18 rats of the main 2 groups loaded with 0,1 mL of ATINE® tincture or “Balm Truskavets’” dissolved in 2,8-3,4 mL of daily water.
The day after the completion of the treating course in all rats assessed the state of the neuro-endocrine-immune complex and metabolism according to the algorithm of the Truskavetsian Scientific School of Balneology and Phytotherapy.
Results. First of all, this study confirmed the previous position that the procedure of loading animals with daily water as a control is not physiologically neutral, but causes chronic adverse stress, which is manifested in changes in a number of variables of the neuro-endocrine-immune complex and metabolism. Therefore, the essential effects of phytocompositions should be assessed by algebraic differences between variables in the experimental and control groups. The essential effects of both phytocompositions were approximately equal. Judging by Cohen’s ds, large (>0,8) effects of phytocompositions are manifested in a decrease in the levels of medium-mass molecules in the blood, two products of lipid peroxidation, corticosterone and adrenals mass, on the one hand, and an increase in antioxidant activity, sympathetic tone, the content of leukocytes in the blood, the bactericidal ability of its neutrophils, the content of macrophages in the spleen and plasma cells in the thymus – on the other hand. Medium (0,8÷0,5) effects of phytocompositions are manifested in an increase in the percentage in the blood of T-helper and B-lymphocytes, killing index of blood neutrophils and activity of super oxide dismutase of erythrocytes while in a decrease in the percentage of 0-lymphocytes in the blood, macrophages in the thymus, phagocytosis index of blood neutrophils, negentropy of leukocytogram and serum potassium. The discriminant analysis method revealed 28 variables of the neuro-endocrine-immune complex and metabolism, by the combination of which intact rats and treated by daily water and phytocompositions are classified with an accuracy of 100%.
Conclusion. Ukrainian phytocompositions balm “Truskavets’” and tea “ATINE” exhibits significantly pronounced approximately equal classic adaptogen properties.
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| institution | DOAJ |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Kazimierz Wielki University |
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| series | Journal of Education, Health and Sport |
| spelling | doaj-art-380d764afad849c1bdb7a98dce5ca3fe2025-08-20T02:56:21ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-08-018310.12775/JEHS.2025.83.64562Nonspecificity of adaptogenic effects of Ukrainian phytocompositions “Balm Truskavets’” and tea ATINE®Igor Bombushkar0https://orcid.org/0000-0003-4260-0736Anatoliy Gozhenko1https://orcid.org/0000-0001-7413-4173Oksana Fihura2https://orcid.org/0000-0002-5711-0484Ivan Savytskyi3https://orcid.org/0000-0002-5841-9993Walery Zukow4https://orcid.org/0000-0002-7675-6117Igor Popovych5https://orcid.org/0000-0002-5664-5591Ukrainian Scientific Research Institute of Medicine of Transport, Odesa, UKRAINEUkrainian Scientific Research Institute of Medicine of Transport, Odesa, UKRAINEIvan Franko State Pedagogical University, Drohobych, UKRAINEInternational Academy of Ecology and Medicine, Kyїv, UKRAINENicolaus Copernicus University, Torun, POLANDInternational Academy of Ecology and Medicine, Kyїv, UKRAINE Background and aim. Recently, members of our informal group in independent experiments on rats, subject to acute stress, have demonstrated stress limiting and antioxidant effects of two Ukrainian Phytocompositions: “Balm Truskavets’” and herbal tea “ATINE”. Despite the qualitative similarity of adaptogenic effects, their correct quantitative comparison is impossible in view of the different models of acute stress, and especially different batteries of tests. The aim of this study is to check the hypothesis of nonspecificity of adaptogenic effects of both phytocompositions by quantitative comparison of their synchronous effects on parameters of the neuro-endocrine-immune complex and the metabolism at rats. Material and methods. The experiment carried up at 42 female rats Wistar line (weight mean 261±25g). 10 animals remained intact with free access to tap daily water, 10 formed a control group, whose members loaded intragastrically with same daily water (2,5 mL/200g) once for 14 days, while 18 rats of the main 2 groups loaded with 0,1 mL of ATINE® tincture or “Balm Truskavets’” dissolved in 2,8-3,4 mL of daily water. The day after the completion of the treating course in all rats assessed the state of the neuro-endocrine-immune complex and metabolism according to the algorithm of the Truskavetsian Scientific School of Balneology and Phytotherapy. Results. First of all, this study confirmed the previous position that the procedure of loading animals with daily water as a control is not physiologically neutral, but causes chronic adverse stress, which is manifested in changes in a number of variables of the neuro-endocrine-immune complex and metabolism. Therefore, the essential effects of phytocompositions should be assessed by algebraic differences between variables in the experimental and control groups. The essential effects of both phytocompositions were approximately equal. Judging by Cohen’s ds, large (>0,8) effects of phytocompositions are manifested in a decrease in the levels of medium-mass molecules in the blood, two products of lipid peroxidation, corticosterone and adrenals mass, on the one hand, and an increase in antioxidant activity, sympathetic tone, the content of leukocytes in the blood, the bactericidal ability of its neutrophils, the content of macrophages in the spleen and plasma cells in the thymus – on the other hand. Medium (0,8÷0,5) effects of phytocompositions are manifested in an increase in the percentage in the blood of T-helper and B-lymphocytes, killing index of blood neutrophils and activity of super oxide dismutase of erythrocytes while in a decrease in the percentage of 0-lymphocytes in the blood, macrophages in the thymus, phagocytosis index of blood neutrophils, negentropy of leukocytogram and serum potassium. The discriminant analysis method revealed 28 variables of the neuro-endocrine-immune complex and metabolism, by the combination of which intact rats and treated by daily water and phytocompositions are classified with an accuracy of 100%. Conclusion. Ukrainian phytocompositions balm “Truskavets’” and tea “ATINE” exhibits significantly pronounced approximately equal classic adaptogen properties. https://apcz.umk.pl/JEHS/article/view/64562Phytocompositions balm “Truskavets’” and tea “ATINE”female ratsstress-limitingimmunomodulatingantioxidant effects |
| spellingShingle | Igor Bombushkar Anatoliy Gozhenko Oksana Fihura Ivan Savytskyi Walery Zukow Igor Popovych Nonspecificity of adaptogenic effects of Ukrainian phytocompositions “Balm Truskavets’” and tea ATINE® Journal of Education, Health and Sport Phytocompositions balm “Truskavets’” and tea “ATINE” female rats stress-limiting immunomodulating antioxidant effects |
| title | Nonspecificity of adaptogenic effects of Ukrainian phytocompositions “Balm Truskavets’” and tea ATINE® |
| title_full | Nonspecificity of adaptogenic effects of Ukrainian phytocompositions “Balm Truskavets’” and tea ATINE® |
| title_fullStr | Nonspecificity of adaptogenic effects of Ukrainian phytocompositions “Balm Truskavets’” and tea ATINE® |
| title_full_unstemmed | Nonspecificity of adaptogenic effects of Ukrainian phytocompositions “Balm Truskavets’” and tea ATINE® |
| title_short | Nonspecificity of adaptogenic effects of Ukrainian phytocompositions “Balm Truskavets’” and tea ATINE® |
| title_sort | nonspecificity of adaptogenic effects of ukrainian phytocompositions balm truskavets and tea atine r |
| topic | Phytocompositions balm “Truskavets’” and tea “ATINE” female rats stress-limiting immunomodulating antioxidant effects |
| url | https://apcz.umk.pl/JEHS/article/view/64562 |
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