Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia
Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exce...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/4239679 |
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| author | Marco Ciacciarelli Gianluca Caruso Marco Rengo Piero Maceroni Carmen Misurale Eleonora D’Armiento Alessandro Polidoro Cristina Napoli Alberto Lombardini Umberto Ceratti Ruben Manuel Luciano Colunga Biancatelli Leonardo Calvosa Romina Milanese Sonia Ferri Teresa Massaro Andrea Lorusso Veronica Sorrentino Vincenzo Petrozza Luigi Iuliano |
| author_facet | Marco Ciacciarelli Gianluca Caruso Marco Rengo Piero Maceroni Carmen Misurale Eleonora D’Armiento Alessandro Polidoro Cristina Napoli Alberto Lombardini Umberto Ceratti Ruben Manuel Luciano Colunga Biancatelli Leonardo Calvosa Romina Milanese Sonia Ferri Teresa Massaro Andrea Lorusso Veronica Sorrentino Vincenzo Petrozza Luigi Iuliano |
| author_sort | Marco Ciacciarelli |
| collection | DOAJ |
| description | Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient’s clinical status deteriorated rapidly, and he died in our department from acute renal failure. |
| format | Article |
| id | doaj-art-38092f9038bd4b77aee17dcd59e56e33 |
| institution | DOAJ |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-38092f9038bd4b77aee17dcd59e56e332025-08-20T03:20:29ZengWileyCase Reports in Endocrinology2090-65012090-651X2020-01-01202010.1155/2020/42396794239679Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe HypoglycemiaMarco Ciacciarelli0Gianluca Caruso1Marco Rengo2Piero Maceroni3Carmen Misurale4Eleonora D’Armiento5Alessandro Polidoro6Cristina Napoli7Alberto Lombardini8Umberto Ceratti9Ruben Manuel Luciano Colunga Biancatelli10Leonardo Calvosa11Romina Milanese12Sonia Ferri13Teresa Massaro14Andrea Lorusso15Veronica Sorrentino16Vincenzo Petrozza17Luigi Iuliano18Department of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Pathology Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Radiological Sciences, Oncology and Pathology, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Radiological Sciences, Oncology and Pathology, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Pathology Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Pathology Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Internal Medicine Unit, ICOT Hospital, “Sapienza” University of Rome, Via Franco Faggiana 1668, Latina 04100, ItalyInsulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient’s clinical status deteriorated rapidly, and he died in our department from acute renal failure.http://dx.doi.org/10.1155/2020/4239679 |
| spellingShingle | Marco Ciacciarelli Gianluca Caruso Marco Rengo Piero Maceroni Carmen Misurale Eleonora D’Armiento Alessandro Polidoro Cristina Napoli Alberto Lombardini Umberto Ceratti Ruben Manuel Luciano Colunga Biancatelli Leonardo Calvosa Romina Milanese Sonia Ferri Teresa Massaro Andrea Lorusso Veronica Sorrentino Vincenzo Petrozza Luigi Iuliano Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia Case Reports in Endocrinology |
| title | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
| title_full | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
| title_fullStr | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
| title_full_unstemmed | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
| title_short | Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia |
| title_sort | malignant insulinoma with multiple liver metastases and hypercalcitoninemia in a patient with type 2 diabetes mellitus presenting as recurrent episodes of diaphoresis due to severe hypoglycemia |
| url | http://dx.doi.org/10.1155/2020/4239679 |
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