Role of Surface Active Agents in Transferosome for Systemic Drug Delivery
The recent utilization of transferosomes (a type of vesicular drug-carrier system) has shown promising results in enhancing the transport of drugs through the skin when administered topically. Phospholipids and surface active agents constitute the primary components of these entities. Surface activ...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2025-01-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1107 |
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| author | Mohsin Hussein Abdulameer Nidhal Khazaal Maraie Zainab H. Mahdi |
| author_facet | Mohsin Hussein Abdulameer Nidhal Khazaal Maraie Zainab H. Mahdi |
| author_sort | Mohsin Hussein Abdulameer |
| collection | DOAJ |
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The recent utilization of transferosomes (a type of vesicular drug-carrier system) has shown promising results in enhancing the transport of drugs through the skin when administered topically. Phospholipids and surface active agents constitute the primary components of these entities. Surface active agents play a crucial role in enhancing the permeability and flexibility of lipid bilayers.
The present research critically examines previous studies to gain insights into the influence of surface active agents on the characteristics and performance of transferosomes. Specifically, it focuses on the effects of these agents on transferosome size, entrapment efficiency (EE), zeta potential, stability, and transdermal flux. The type of surface active agent generally exerts a notable influence on the size of vesicles, encapsulation efficiency (EE), and zeta potential. This phenomenon could potentially be attributed to variations in the hydrophilic-lipophilic balance (HLB), the hydrophilicity of the surface active agent, and the length of the carbon chain. Therefore, it is imperative to investigate the influence of surface active agent properties in the development of transferosomes. The evaluation of the cytocompatibility of surface active compounds was also incorporated into the study.
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| format | Article |
| id | doaj-art-380773b236d1480988617954306e0960 |
| institution | Kabale University |
| issn | 1815-0993 2959-183X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj-art-380773b236d1480988617954306e09602025-01-24T13:47:27ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2025-01-0125110.32947/ajps.v25i1.1107Role of Surface Active Agents in Transferosome for Systemic Drug DeliveryMohsin Hussein Abdulameer0Nidhal Khazaal Maraie1Zainab H. Mahdi2Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, IraqDepartment of Pharmaceutics, College of Pharmacy, Al Farahidi University, Baghdad, IraqDepartment of Pharmaceutical Sciences and Pharmaceutics, Applied Science Private University, Amman, Jordan The recent utilization of transferosomes (a type of vesicular drug-carrier system) has shown promising results in enhancing the transport of drugs through the skin when administered topically. Phospholipids and surface active agents constitute the primary components of these entities. Surface active agents play a crucial role in enhancing the permeability and flexibility of lipid bilayers. The present research critically examines previous studies to gain insights into the influence of surface active agents on the characteristics and performance of transferosomes. Specifically, it focuses on the effects of these agents on transferosome size, entrapment efficiency (EE), zeta potential, stability, and transdermal flux. The type of surface active agent generally exerts a notable influence on the size of vesicles, encapsulation efficiency (EE), and zeta potential. This phenomenon could potentially be attributed to variations in the hydrophilic-lipophilic balance (HLB), the hydrophilicity of the surface active agent, and the length of the carbon chain. Therefore, it is imperative to investigate the influence of surface active agent properties in the development of transferosomes. The evaluation of the cytocompatibility of surface active compounds was also incorporated into the study. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1107lipid based vesiclessurface active agentsurfactanttransferosome |
| spellingShingle | Mohsin Hussein Abdulameer Nidhal Khazaal Maraie Zainab H. Mahdi Role of Surface Active Agents in Transferosome for Systemic Drug Delivery Al-Mustansiriyah Journal of Pharmaceutical Sciences lipid based vesicles surface active agent surfactant transferosome |
| title | Role of Surface Active Agents in Transferosome for Systemic Drug Delivery |
| title_full | Role of Surface Active Agents in Transferosome for Systemic Drug Delivery |
| title_fullStr | Role of Surface Active Agents in Transferosome for Systemic Drug Delivery |
| title_full_unstemmed | Role of Surface Active Agents in Transferosome for Systemic Drug Delivery |
| title_short | Role of Surface Active Agents in Transferosome for Systemic Drug Delivery |
| title_sort | role of surface active agents in transferosome for systemic drug delivery |
| topic | lipid based vesicles surface active agent surfactant transferosome |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1107 |
| work_keys_str_mv | AT mohsinhusseinabdulameer roleofsurfaceactiveagentsintransferosomeforsystemicdrugdelivery AT nidhalkhazaalmaraie roleofsurfaceactiveagentsintransferosomeforsystemicdrugdelivery AT zainabhmahdi roleofsurfaceactiveagentsintransferosomeforsystemicdrugdelivery |