Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal Cortex
The entorhinal cortex receives a large projection from the piriform cortex, and synaptic plasticity in this pathway may affect olfactory processing. In vitro whole cell recordings have been used here to investigate postsynaptic signalling mechanisms that mediate the induction of long-term synaptic d...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2008/840374 |
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| author | Saïd Kourrich Stephen D. Glasgow Douglas A. Caruana C. Andrew Chapman |
| author_facet | Saïd Kourrich Stephen D. Glasgow Douglas A. Caruana C. Andrew Chapman |
| author_sort | Saïd Kourrich |
| collection | DOAJ |
| description | The entorhinal cortex receives a large projection from the piriform cortex, and synaptic plasticity in this pathway may affect olfactory processing. In vitro whole cell recordings have been used here to investigate postsynaptic signalling mechanisms that mediate the induction of long-term synaptic depression (LTD) in layer II entorhinal cortex cells. To induce LTD, pairs of pulses, using a 30-millisecond interval, were delivered at 1 Hz for 15 minutes. Induction of LTD was blocked by the NMDA receptor antagonist APV and by the calcium chelator BAPTA, consistent with a requirement for calcium influx via NMDA receptors. Induction of LTD was blocked when the FK506 was included in the intracellular solution to block the phosphatase calcineurin. Okadaic acid, which blocks activation of protein phosphatases 1 and 2a, also prevented LTD. Activation of protein phosphatases following calcium influx therefore contributes to induction of LTD in layer II of the entorhinal cortex. |
| format | Article |
| id | doaj-art-38049944a7994b4084db466f0b0970f4 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-38049944a7994b4084db466f0b0970f42025-02-03T05:46:47ZengWileyNeural Plasticity2090-59041687-54432008-01-01200810.1155/2008/840374840374Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal CortexSaïd Kourrich0Stephen D. Glasgow1Douglas A. Caruana2C. Andrew Chapman3Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, CanadaCenter for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, CanadaCenter for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, CanadaCenter for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montréal, QC, H4B 1R6, CanadaThe entorhinal cortex receives a large projection from the piriform cortex, and synaptic plasticity in this pathway may affect olfactory processing. In vitro whole cell recordings have been used here to investigate postsynaptic signalling mechanisms that mediate the induction of long-term synaptic depression (LTD) in layer II entorhinal cortex cells. To induce LTD, pairs of pulses, using a 30-millisecond interval, were delivered at 1 Hz for 15 minutes. Induction of LTD was blocked by the NMDA receptor antagonist APV and by the calcium chelator BAPTA, consistent with a requirement for calcium influx via NMDA receptors. Induction of LTD was blocked when the FK506 was included in the intracellular solution to block the phosphatase calcineurin. Okadaic acid, which blocks activation of protein phosphatases 1 and 2a, also prevented LTD. Activation of protein phosphatases following calcium influx therefore contributes to induction of LTD in layer II of the entorhinal cortex.http://dx.doi.org/10.1155/2008/840374 |
| spellingShingle | Saïd Kourrich Stephen D. Glasgow Douglas A. Caruana C. Andrew Chapman Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal Cortex Neural Plasticity |
| title | Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal Cortex |
| title_full | Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal Cortex |
| title_fullStr | Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal Cortex |
| title_full_unstemmed | Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal Cortex |
| title_short | Postsynaptic Signals Mediating Induction of Long-Term Synaptic Depression in the Entorhinal Cortex |
| title_sort | postsynaptic signals mediating induction of long term synaptic depression in the entorhinal cortex |
| url | http://dx.doi.org/10.1155/2008/840374 |
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