Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats
Goji berry (Lycium barbarum), characterized as a functional food, has been shown to be effective in the prevention and/or treatment of obesity. This study investigated the effects of Goji berry supplementation (250 mg/kg) on the intestine of male Wistar rats, from 70 to 130 days (group OGB) or 21 to...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000052 |
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| author | Samara Cristina Dossena Isabela Ramos Mariano Furlan Maria Montserrat Diaz Pedrosa Rosângela Fernandes Garcia Fernando Carlos de Sousa Maria Raquel Marçal Natali |
| author_facet | Samara Cristina Dossena Isabela Ramos Mariano Furlan Maria Montserrat Diaz Pedrosa Rosângela Fernandes Garcia Fernando Carlos de Sousa Maria Raquel Marçal Natali |
| author_sort | Samara Cristina Dossena |
| collection | DOAJ |
| description | Goji berry (Lycium barbarum), characterized as a functional food, has been shown to be effective in the prevention and/or treatment of obesity. This study investigated the effects of Goji berry supplementation (250 mg/kg) on the intestine of male Wistar rats, from 70 to 130 days (group OGB) or 21 to 130 days (group OPR) of age, with obesity induced by simple carbohydrate-rich diet. The diet did not change the morphology or the thickness of the proximal colon wall but increased the proportion of small neurons in the myoenteric plexus. The use of the Goji berry extract had therapeutic effect on the obese animals (group OGB), decreasing body mass and mesenteric fat and increasing HDL cholesterol. As a preventive agent (group OPR) it reduced the body mass index, preserved the percentage of neutral mucins-producing goblet cells and increased the incidence of large neurons in the colonic myoenteric plexus. The use of the Goji berry extract is a promising alternative for the preservation and restoration of the intestinal structure and organization compromised by an obesogenic diet. |
| format | Article |
| id | doaj-art-3800be001760419e965cdb42813be8d5 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-3800be001760419e965cdb42813be8d52025-02-09T04:59:53ZengElsevierJournal of Functional Foods1756-46462025-02-01125106663Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese ratsSamara Cristina Dossena0Isabela Ramos Mariano Furlan1Maria Montserrat Diaz Pedrosa2Rosângela Fernandes Garcia3Fernando Carlos de Sousa4Maria Raquel Marçal Natali5Program of Graduate Studies in Biological Sciences, State University of Maringá, Av. Colombo, 5790 - 87020-900, Maringá, Paraná, Brazil; Corresponding author at: Program of Graduate Studies in Biological Sciences, State University of Maringá, Av. Colombo, 5790 - Zona 7, Maringá, Paraná 87020-900, Brazil.Program of Graduate Studies in Biological Sciences, State University of Maringá, Av. Colombo, 5790 - 87020-900, Maringá, Paraná, BrazilDepartment of Physiological Sciences, State University of Maringá, Av. Colombo, 5790 - 87020-900, Maringá, Paraná, BrazilDepartment of Physiological Sciences, State University of Maringá, Av. Colombo, 5790 - 87020-900, Maringá, Paraná, BrazilFederal Technologic University of Paraná, Boa Esperança Road, km 04 - 85660-000, Dois Vizinhos, Paraná, BrazilDepartment of Morphological Sciences, State University of Maringá, Av. Colombo, 5790 - 87020-900, Maringá, Paraná, BrazilGoji berry (Lycium barbarum), characterized as a functional food, has been shown to be effective in the prevention and/or treatment of obesity. This study investigated the effects of Goji berry supplementation (250 mg/kg) on the intestine of male Wistar rats, from 70 to 130 days (group OGB) or 21 to 130 days (group OPR) of age, with obesity induced by simple carbohydrate-rich diet. The diet did not change the morphology or the thickness of the proximal colon wall but increased the proportion of small neurons in the myoenteric plexus. The use of the Goji berry extract had therapeutic effect on the obese animals (group OGB), decreasing body mass and mesenteric fat and increasing HDL cholesterol. As a preventive agent (group OPR) it reduced the body mass index, preserved the percentage of neutral mucins-producing goblet cells and increased the incidence of large neurons in the colonic myoenteric plexus. The use of the Goji berry extract is a promising alternative for the preservation and restoration of the intestinal structure and organization compromised by an obesogenic diet.http://www.sciencedirect.com/science/article/pii/S1756464625000052Myoenteric neuronal areaColonic intestinal morphologyGoblet cellsSimple carbohydrate-rich diet |
| spellingShingle | Samara Cristina Dossena Isabela Ramos Mariano Furlan Maria Montserrat Diaz Pedrosa Rosângela Fernandes Garcia Fernando Carlos de Sousa Maria Raquel Marçal Natali Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats Journal of Functional Foods Myoenteric neuronal area Colonic intestinal morphology Goblet cells Simple carbohydrate-rich diet |
| title | Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats |
| title_full | Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats |
| title_fullStr | Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats |
| title_full_unstemmed | Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats |
| title_short | Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats |
| title_sort | goji berry lycium barbarum has positive effects on the mucosa and colonic myoenteric innervation of obese rats |
| topic | Myoenteric neuronal area Colonic intestinal morphology Goblet cells Simple carbohydrate-rich diet |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000052 |
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