Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological Activities
The synthesis and spectroscopic characterization of new axially ligated indium(III) porphyrin complexes were reported. Chloroindium(III) porphyrin (TPPIn-Cl) was obtained in good yield by treating the corresponding free base with indium trichloride. The action of the different phenols on chloroderi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2014/865407 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563837308502016 |
|---|---|
| author | Gauri D. Bajju Altaf Ahmed Deepmala Gupta Ashu Kapahi Gita Devi |
| author_facet | Gauri D. Bajju Altaf Ahmed Deepmala Gupta Ashu Kapahi Gita Devi |
| author_sort | Gauri D. Bajju |
| collection | DOAJ |
| description | The synthesis and spectroscopic characterization of new axially ligated indium(III) porphyrin complexes were reported. Chloroindium(III) porphyrin (TPPIn-Cl) was obtained in good yield by treating the corresponding free base with indium trichloride. The action of the different phenols on chloroderivatives (TPPIn-Cl) led to the corresponding phenolato complexes (TPPIn-X). These derivatives were characterized on the basis of mass spectrometry, 1H-NMR, IR, and UV-visible data. The separation and isolation of these derivatives have been achieved through chromatography. The spectral properties of free base porphyrin and its corresponding metallated and axially ligated indium(III) porphyrin compounds were compared with each other. A detailed analysis of UV-Vis, 1H-NMR, and IR suggested the transformation from free base porphyrin to indium(III) porphyrin. Besides, 13C-NMR and fluorescence spectra were also reported and interpreted. The stability of these derivatives has also been studied through thermogravimetry. The complexes were also screened for anticancerous activities. Among all the complexes, 4-MePhO-InTPP shows highest anticancerous activity. The title complexe, TPPIn-X (where X = different phenolates), represents a five-coordinate indium(III) porphyrin complex in a square-pyramidal geometry with the phenolate anion as the axial ligand. |
| format | Article |
| id | doaj-art-37fe2d66cd4d4ee6ab64a7161a40f7f2 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-37fe2d66cd4d4ee6ab64a7161a40f7f22025-02-03T01:12:26ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2014-01-01201410.1155/2014/865407865407Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological ActivitiesGauri D. Bajju0Altaf Ahmed1Deepmala Gupta2Ashu Kapahi3Gita Devi4 P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, India P.G. Department of Chemistry, University of Jammu, Jammu and Kashmir 180006, IndiaThe synthesis and spectroscopic characterization of new axially ligated indium(III) porphyrin complexes were reported. Chloroindium(III) porphyrin (TPPIn-Cl) was obtained in good yield by treating the corresponding free base with indium trichloride. The action of the different phenols on chloroderivatives (TPPIn-Cl) led to the corresponding phenolato complexes (TPPIn-X). These derivatives were characterized on the basis of mass spectrometry, 1H-NMR, IR, and UV-visible data. The separation and isolation of these derivatives have been achieved through chromatography. The spectral properties of free base porphyrin and its corresponding metallated and axially ligated indium(III) porphyrin compounds were compared with each other. A detailed analysis of UV-Vis, 1H-NMR, and IR suggested the transformation from free base porphyrin to indium(III) porphyrin. Besides, 13C-NMR and fluorescence spectra were also reported and interpreted. The stability of these derivatives has also been studied through thermogravimetry. The complexes were also screened for anticancerous activities. Among all the complexes, 4-MePhO-InTPP shows highest anticancerous activity. The title complexe, TPPIn-X (where X = different phenolates), represents a five-coordinate indium(III) porphyrin complex in a square-pyramidal geometry with the phenolate anion as the axial ligand.http://dx.doi.org/10.1155/2014/865407 |
| spellingShingle | Gauri D. Bajju Altaf Ahmed Deepmala Gupta Ashu Kapahi Gita Devi Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological Activities Bioinorganic Chemistry and Applications |
| title | Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological Activities |
| title_full | Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological Activities |
| title_fullStr | Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological Activities |
| title_full_unstemmed | Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological Activities |
| title_short | Synthesis and Spectroscopic Characterization of Some New Axially Ligated Indium(III) Macrocyclic Complexes and Their Biological Activities |
| title_sort | synthesis and spectroscopic characterization of some new axially ligated indium iii macrocyclic complexes and their biological activities |
| url | http://dx.doi.org/10.1155/2014/865407 |
| work_keys_str_mv | AT gauridbajju synthesisandspectroscopiccharacterizationofsomenewaxiallyligatedindiumiiimacrocycliccomplexesandtheirbiologicalactivities AT altafahmed synthesisandspectroscopiccharacterizationofsomenewaxiallyligatedindiumiiimacrocycliccomplexesandtheirbiologicalactivities AT deepmalagupta synthesisandspectroscopiccharacterizationofsomenewaxiallyligatedindiumiiimacrocycliccomplexesandtheirbiologicalactivities AT ashukapahi synthesisandspectroscopiccharacterizationofsomenewaxiallyligatedindiumiiimacrocycliccomplexesandtheirbiologicalactivities AT gitadevi synthesisandspectroscopiccharacterizationofsomenewaxiallyligatedindiumiiimacrocycliccomplexesandtheirbiologicalactivities |