Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy
Introduction: Vaccination against coronavirus disease-19 (COVID-19) is highly effective in preventing severe disease and mortality. Adenoviral vector and mRNA vaccines were effective against intensive care unit (ICU) admission, but the effectiveness of inactivated vaccine on ICU admission was uncle...
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The Journal of Infection in Developing Countries
2024-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/18342 |
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| author | Süleyman Yıldırım Cenk Kirakli Yeliz Özdemir Selma Tosun Sinem Ermin Gülru Polat Celalettin Yılmaz Semra Bilaçeroğlu Bilge Salık Berna Kömürcüoğlu İlker Ödemiş Şükran Köse Uğur Uzun Gaye Aydın Enver İlhan |
| author_facet | Süleyman Yıldırım Cenk Kirakli Yeliz Özdemir Selma Tosun Sinem Ermin Gülru Polat Celalettin Yılmaz Semra Bilaçeroğlu Bilge Salık Berna Kömürcüoğlu İlker Ödemiş Şükran Köse Uğur Uzun Gaye Aydın Enver İlhan |
| author_sort | Süleyman Yıldırım |
| collection | DOAJ |
| description |
Introduction: Vaccination against coronavirus disease-19 (COVID-19) is highly effective in preventing severe disease and mortality. Adenoviral vector and mRNA vaccines were effective against intensive care unit (ICU) admission, but the effectiveness of inactivated vaccine on ICU admission was unclear. We aimed to evaluate the effect of vaccination status on ICU admission in hospitalized COVID-19 patients in a country with heterologous vaccination policy.
Methodology: This is a retrospective multicenter study conducted in three hospitals in Izmir, Turkey between 1 January 2021 and 31 March 2022. Patients aged ≥ 18 years and hospitalized due to COVID-19 were included in the study. Patients who had never been vaccinated and patients who had been vaccinated with a single dose were considered unvaccinated. A logistic regression analysis was performed for evaluating risk factors for ICU admission.
Results: A total of 2,110 patients were included in the final analysis. The median age was 66 years (IQR, 53-76 years) and 54% of the patients were vaccinated. During the study period, 407 patients (19.3%) were transferred to the ICU due to disease severity. Patients who were admitted to the ICU were older (median age 68 vs. 65 years, p < 0.001); and the number of unvaccinated individuals was higher among ICU patients (57% vs. 45%, p < 0.001). In multivariate regression analysis, being unvaccinated was found to be the most important independent risk factor for ICU admission with an OR of 2.06 (95% CI, 1.64-2.59).
Conclusions: Vaccination against COVID-19 is effective against ICU admission and hospital mortality.
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| format | Article |
| id | doaj-art-37fd630d08e04ca99e2325c92232ef4f |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-37fd630d08e04ca99e2325c92232ef4f2025-08-20T02:16:06ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-04-01180410.3855/jidc.18342Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policySüleyman Yıldırım0Cenk Kirakli1Yeliz Özdemir2Selma Tosun3Sinem Ermin4Gülru Polat5Celalettin Yılmaz6Semra Bilaçeroğlu7Bilge Salık8Berna Kömürcüoğlu9İlker Ödemiş10Şükran Köse11Uğur Uzun12Gaye Aydın13Enver İlhan14University of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Intensive Care Unit, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Intensive Care Unit, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Bozyaka Training and Research Hospital, Department of Infectious Disease and Clinical Microbiology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Bozyaka Training and Research Hospital, Department of Infectious Disease and Clinical Microbiology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Department of Pulmonology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Department of Pulmonology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Department of Pulmonology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Department of Pulmonology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Department of Pulmonology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir School of Medicine, Dr. Suat Seren Chest Disease and Surgery Training and Research Hospital, Department of Pulmonology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Faculty of Medicine, Izmir Tepecik Training and Research Hospital, Department of Infectious Disease and Clinical Microbiology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Faculty of Medicine, Izmir Tepecik Training and Research Hospital, Department of Infectious Disease and Clinical Microbiology, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Faculty of Medicine, Izmir Tepecik Training and Research Hospital, Department of Anesthesiology and Reanimation, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Faculty of Medicine, Izmir Tepecik Training and Research Hospital, Department of Anesthesiology and Reanimation, Izmir, TurkeyUniversity of Health Sciences Turkey, Izmir Faculty of Medicine, Bozyaka Research and Training Hospital, Izmir, Turkey Introduction: Vaccination against coronavirus disease-19 (COVID-19) is highly effective in preventing severe disease and mortality. Adenoviral vector and mRNA vaccines were effective against intensive care unit (ICU) admission, but the effectiveness of inactivated vaccine on ICU admission was unclear. We aimed to evaluate the effect of vaccination status on ICU admission in hospitalized COVID-19 patients in a country with heterologous vaccination policy. Methodology: This is a retrospective multicenter study conducted in three hospitals in Izmir, Turkey between 1 January 2021 and 31 March 2022. Patients aged ≥ 18 years and hospitalized due to COVID-19 were included in the study. Patients who had never been vaccinated and patients who had been vaccinated with a single dose were considered unvaccinated. A logistic regression analysis was performed for evaluating risk factors for ICU admission. Results: A total of 2,110 patients were included in the final analysis. The median age was 66 years (IQR, 53-76 years) and 54% of the patients were vaccinated. During the study period, 407 patients (19.3%) were transferred to the ICU due to disease severity. Patients who were admitted to the ICU were older (median age 68 vs. 65 years, p < 0.001); and the number of unvaccinated individuals was higher among ICU patients (57% vs. 45%, p < 0.001). In multivariate regression analysis, being unvaccinated was found to be the most important independent risk factor for ICU admission with an OR of 2.06 (95% CI, 1.64-2.59). Conclusions: Vaccination against COVID-19 is effective against ICU admission and hospital mortality. https://jidc.org/index.php/journal/article/view/18342COVID-19vaccinationhospitalizationintensive care unit |
| spellingShingle | Süleyman Yıldırım Cenk Kirakli Yeliz Özdemir Selma Tosun Sinem Ermin Gülru Polat Celalettin Yılmaz Semra Bilaçeroğlu Bilge Salık Berna Kömürcüoğlu İlker Ödemiş Şükran Köse Uğur Uzun Gaye Aydın Enver İlhan Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy Journal of Infection in Developing Countries COVID-19 vaccination hospitalization intensive care unit |
| title | Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy |
| title_full | Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy |
| title_fullStr | Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy |
| title_full_unstemmed | Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy |
| title_short | Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy |
| title_sort | impact of vaccination on icu admissions of hospitalized covid 19 patients in a country with a heterologous vaccine policy |
| topic | COVID-19 vaccination hospitalization intensive care unit |
| url | https://jidc.org/index.php/journal/article/view/18342 |
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