Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection
Orthorubulavirus parotitis, known as the mumps virus (MuV), can cause severe complications, including deafness and reduced fertility in humans. Developing preventive strategies against MuV infections is essential to mitigate these risks. We previously established an effective method for producing a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006595 |
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| author | Tadanobu Takahashi Yuuki Kurebayashi Shunsuke Suzuki Kobun Konagaya Yutaka Narimichi Eiji Kobatake Hirofumi Fukudome Toshiyuki Yamaguchi Fumihiko Sakai Toshinobu Arai Toshihide Kabuki Akira Minami Hideyuki Takeuchi |
| author_facet | Tadanobu Takahashi Yuuki Kurebayashi Shunsuke Suzuki Kobun Konagaya Yutaka Narimichi Eiji Kobatake Hirofumi Fukudome Toshiyuki Yamaguchi Fumihiko Sakai Toshinobu Arai Toshihide Kabuki Akira Minami Hideyuki Takeuchi |
| author_sort | Tadanobu Takahashi |
| collection | DOAJ |
| description | Orthorubulavirus parotitis, known as the mumps virus (MuV), can cause severe complications, including deafness and reduced fertility in humans. Developing preventive strategies against MuV infections is essential to mitigate these risks. We previously established an effective method for producing a milk-derived sialylglycopeptide (MSGP) concentrate from glycomacropeptide (GMP) in bovine milk using protease treatment. This MSGP concentrate was rich in short glycans containing α2–3 linked sialic acids, resembling the MuV binding receptors, which may contribute to inhibiting MuV infection. Our findings revealed that the MSGP concentrate significantly reduced MuV infection compared to the GMP concentrate. The hemagglutination inhibition of the MSGP concentrate was 2–8 times higher than that of the GMP concentrate, suggesting that the MSGP concentrate inhibits MuV infection by preventing receptor binding. These results highlight the potential of the MSGP concentrate as a food-derived functional material for preventing MuV infections. |
| format | Article |
| id | doaj-art-37fd181580f44517860146dd976fe8f7 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-37fd181580f44517860146dd976fe8f72025-01-12T05:24:48ZengElsevierJournal of Functional Foods1756-46462025-01-01124106656Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infectionTadanobu Takahashi0Yuuki Kurebayashi1Shunsuke Suzuki2Kobun Konagaya3Yutaka Narimichi4Eiji Kobatake5Hirofumi Fukudome6Toshiyuki Yamaguchi7Fumihiko Sakai8Toshinobu Arai9Toshihide Kabuki10Akira Minami11Hideyuki Takeuchi12Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 4228526, Japan; Corresponding authors.Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 4228526, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 4228526, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 4228526, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 4228526, JapanMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 3501165, JapanMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 3501165, JapanMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 3501165, JapanMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 3501165, JapanMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 3501165, JapanMilk Science Research Institute, MEGMILK SNOW BRAND Co., Ltd., 1-1-2 Minamidai, Kawagoe-shi, Saitama 3501165, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 4228526, Japan; Department of Functional Morphology, Faculty of Pharmacy, Juntendo University, 6-8-1 Hinode, Urayasu-shi, Chiba 2790013, JapanDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 4228526, Japan; Corresponding authors.Orthorubulavirus parotitis, known as the mumps virus (MuV), can cause severe complications, including deafness and reduced fertility in humans. Developing preventive strategies against MuV infections is essential to mitigate these risks. We previously established an effective method for producing a milk-derived sialylglycopeptide (MSGP) concentrate from glycomacropeptide (GMP) in bovine milk using protease treatment. This MSGP concentrate was rich in short glycans containing α2–3 linked sialic acids, resembling the MuV binding receptors, which may contribute to inhibiting MuV infection. Our findings revealed that the MSGP concentrate significantly reduced MuV infection compared to the GMP concentrate. The hemagglutination inhibition of the MSGP concentrate was 2–8 times higher than that of the GMP concentrate, suggesting that the MSGP concentrate inhibits MuV infection by preventing receptor binding. These results highlight the potential of the MSGP concentrate as a food-derived functional material for preventing MuV infections.http://www.sciencedirect.com/science/article/pii/S1756464624006595HemagglutinationMilkMumps virusInfectionInhibitionSialylglycopeptide |
| spellingShingle | Tadanobu Takahashi Yuuki Kurebayashi Shunsuke Suzuki Kobun Konagaya Yutaka Narimichi Eiji Kobatake Hirofumi Fukudome Toshiyuki Yamaguchi Fumihiko Sakai Toshinobu Arai Toshihide Kabuki Akira Minami Hideyuki Takeuchi Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection Journal of Functional Foods Hemagglutination Milk Mumps virus Infection Inhibition Sialylglycopeptide |
| title | Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection |
| title_full | Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection |
| title_fullStr | Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection |
| title_full_unstemmed | Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection |
| title_short | Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection |
| title_sort | bovine milk derived sialylglycopeptide concentrate suppresses mumps virus infection |
| topic | Hemagglutination Milk Mumps virus Infection Inhibition Sialylglycopeptide |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006595 |
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