Bovine milk-derived sialylglycopeptide concentrate suppresses mumps virus infection
Orthorubulavirus parotitis, known as the mumps virus (MuV), can cause severe complications, including deafness and reduced fertility in humans. Developing preventive strategies against MuV infections is essential to mitigate these risks. We previously established an effective method for producing a...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006595 |
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| Summary: | Orthorubulavirus parotitis, known as the mumps virus (MuV), can cause severe complications, including deafness and reduced fertility in humans. Developing preventive strategies against MuV infections is essential to mitigate these risks. We previously established an effective method for producing a milk-derived sialylglycopeptide (MSGP) concentrate from glycomacropeptide (GMP) in bovine milk using protease treatment. This MSGP concentrate was rich in short glycans containing α2–3 linked sialic acids, resembling the MuV binding receptors, which may contribute to inhibiting MuV infection. Our findings revealed that the MSGP concentrate significantly reduced MuV infection compared to the GMP concentrate. The hemagglutination inhibition of the MSGP concentrate was 2–8 times higher than that of the GMP concentrate, suggesting that the MSGP concentrate inhibits MuV infection by preventing receptor binding. These results highlight the potential of the MSGP concentrate as a food-derived functional material for preventing MuV infections. |
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| ISSN: | 1756-4646 |