Small molecule inhibition of RNA binding proteins in haematologic cancer
In recent years, advances in biomedicine have revealed an important role for post-transcriptional mechanisms of gene expression regulation in pathologic conditions. In cancer in general and leukaemia specifically, RNA binding proteins have emerged as important regulator of RNA homoeostasis that are...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2303558 |
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| author | Amit K. Jaiswal Michelle L. Thaxton Georgia M. Scherer Jacob P. Sorrentino Neil K. Garg Dinesh S. Rao |
| author_facet | Amit K. Jaiswal Michelle L. Thaxton Georgia M. Scherer Jacob P. Sorrentino Neil K. Garg Dinesh S. Rao |
| author_sort | Amit K. Jaiswal |
| collection | DOAJ |
| description | In recent years, advances in biomedicine have revealed an important role for post-transcriptional mechanisms of gene expression regulation in pathologic conditions. In cancer in general and leukaemia specifically, RNA binding proteins have emerged as important regulator of RNA homoeostasis that are often dysregulated in the disease state. Having established the importance of these pathogenetic mechanisms, there have been a number of efforts to target RNA binding proteins using oligonucleotide-based strategies, as well as with small organic molecules. The field is at an exciting inflection point with the convergence of biomedical knowledge, small molecule screening strategies and improved chemical methods for synthesis and construction of sophisticated small molecules. Here, we review the mechanisms of post-transcriptional gene regulation, specifically in leukaemia, current small-molecule based efforts to target RNA binding proteins, and future prospects. |
| format | Article |
| id | doaj-art-37f8ee50b32748519cd1e2eefcd9acb6 |
| institution | DOAJ |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-37f8ee50b32748519cd1e2eefcd9acb62025-08-20T02:50:03ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-0121127628910.1080/15476286.2024.2303558Small molecule inhibition of RNA binding proteins in haematologic cancerAmit K. Jaiswal0Michelle L. Thaxton1Georgia M. Scherer2Jacob P. Sorrentino3Neil K. Garg4Dinesh S. Rao5Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USADepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USADepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USADepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USADepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USADepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USAIn recent years, advances in biomedicine have revealed an important role for post-transcriptional mechanisms of gene expression regulation in pathologic conditions. In cancer in general and leukaemia specifically, RNA binding proteins have emerged as important regulator of RNA homoeostasis that are often dysregulated in the disease state. Having established the importance of these pathogenetic mechanisms, there have been a number of efforts to target RNA binding proteins using oligonucleotide-based strategies, as well as with small organic molecules. The field is at an exciting inflection point with the convergence of biomedical knowledge, small molecule screening strategies and improved chemical methods for synthesis and construction of sophisticated small molecules. Here, we review the mechanisms of post-transcriptional gene regulation, specifically in leukaemia, current small-molecule based efforts to target RNA binding proteins, and future prospects.https://www.tandfonline.com/doi/10.1080/15476286.2024.2303558RNA binding proteinspost-transcriptional gene regulationdrug discoveryAcute leukaemiaRNA splicing |
| spellingShingle | Amit K. Jaiswal Michelle L. Thaxton Georgia M. Scherer Jacob P. Sorrentino Neil K. Garg Dinesh S. Rao Small molecule inhibition of RNA binding proteins in haematologic cancer RNA Biology RNA binding proteins post-transcriptional gene regulation drug discovery Acute leukaemia RNA splicing |
| title | Small molecule inhibition of RNA binding proteins in haematologic cancer |
| title_full | Small molecule inhibition of RNA binding proteins in haematologic cancer |
| title_fullStr | Small molecule inhibition of RNA binding proteins in haematologic cancer |
| title_full_unstemmed | Small molecule inhibition of RNA binding proteins in haematologic cancer |
| title_short | Small molecule inhibition of RNA binding proteins in haematologic cancer |
| title_sort | small molecule inhibition of rna binding proteins in haematologic cancer |
| topic | RNA binding proteins post-transcriptional gene regulation drug discovery Acute leukaemia RNA splicing |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2303558 |
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