A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing
Abstract Photocatalysis has greatly advanced in organic synthesis but still confronts challenges, including light attenuation in reaction media and excessive solvent utilization. These issues lead to inefficiencies, particularly in heterogeneous cloudy mixtures and in scaling-up applications. Integr...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-59358-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850206202759217152 |
|---|---|
| author | Deshen Kong Liang Yi Alice Nanni Magnus Rueping |
| author_facet | Deshen Kong Liang Yi Alice Nanni Magnus Rueping |
| author_sort | Deshen Kong |
| collection | DOAJ |
| description | Abstract Photocatalysis has greatly advanced in organic synthesis but still confronts challenges, including light attenuation in reaction media and excessive solvent utilization. These issues lead to inefficiencies, particularly in heterogeneous cloudy mixtures and in scaling-up applications. Integrating photocatalysis with mechanochemistry offers a nascent but promising solution to these challenges. Herein, we present a scalable photo-mechanochemical platform that combines visible-light photocatalysis with Resonant Acoustic Mixing (RAM), enabling efficient cross-coupling reactions under solvent-minimised conditions. This approach demonstrates broad substrate tolerance, accommodating a variety of aryl (hetero) halides and N-, O-, P-, S-nucleophiles. The protocol supports scaling up to 300 mmol, representing a 1500-fold increase, while maintaining exceptionally low catalyst loading and achieving up to 9800 turnover numbers (TON). The generality of this platform is further validated by its applicability to other synthetic transformations. |
| format | Article |
| id | doaj-art-37f75db202534bb18dda01aff1d3e9a1 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-37f75db202534bb18dda01aff1d3e9a12025-08-20T02:10:54ZengNature PortfolioNature Communications2041-17232025-04-0116111010.1038/s41467-025-59358-1A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixingDeshen Kong0Liang Yi1Alice Nanni2Magnus Rueping3KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST)KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST)KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST)KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST)Abstract Photocatalysis has greatly advanced in organic synthesis but still confronts challenges, including light attenuation in reaction media and excessive solvent utilization. These issues lead to inefficiencies, particularly in heterogeneous cloudy mixtures and in scaling-up applications. Integrating photocatalysis with mechanochemistry offers a nascent but promising solution to these challenges. Herein, we present a scalable photo-mechanochemical platform that combines visible-light photocatalysis with Resonant Acoustic Mixing (RAM), enabling efficient cross-coupling reactions under solvent-minimised conditions. This approach demonstrates broad substrate tolerance, accommodating a variety of aryl (hetero) halides and N-, O-, P-, S-nucleophiles. The protocol supports scaling up to 300 mmol, representing a 1500-fold increase, while maintaining exceptionally low catalyst loading and achieving up to 9800 turnover numbers (TON). The generality of this platform is further validated by its applicability to other synthetic transformations.https://doi.org/10.1038/s41467-025-59358-1 |
| spellingShingle | Deshen Kong Liang Yi Alice Nanni Magnus Rueping A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing Nature Communications |
| title | A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing |
| title_full | A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing |
| title_fullStr | A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing |
| title_full_unstemmed | A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing |
| title_short | A scalable photo-mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing |
| title_sort | scalable photo mechanochemical platform for sustainable photoredox catalysis by resonant acoustic mixing |
| url | https://doi.org/10.1038/s41467-025-59358-1 |
| work_keys_str_mv | AT deshenkong ascalablephotomechanochemicalplatformforsustainablephotoredoxcatalysisbyresonantacousticmixing AT liangyi ascalablephotomechanochemicalplatformforsustainablephotoredoxcatalysisbyresonantacousticmixing AT alicenanni ascalablephotomechanochemicalplatformforsustainablephotoredoxcatalysisbyresonantacousticmixing AT magnusrueping ascalablephotomechanochemicalplatformforsustainablephotoredoxcatalysisbyresonantacousticmixing AT deshenkong scalablephotomechanochemicalplatformforsustainablephotoredoxcatalysisbyresonantacousticmixing AT liangyi scalablephotomechanochemicalplatformforsustainablephotoredoxcatalysisbyresonantacousticmixing AT alicenanni scalablephotomechanochemicalplatformforsustainablephotoredoxcatalysisbyresonantacousticmixing AT magnusrueping scalablephotomechanochemicalplatformforsustainablephotoredoxcatalysisbyresonantacousticmixing |