NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors

NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors

Abstract Although immune checkpoint inhibitors (ICIs) have elicited desirable clinical outcomes, their effective application remains an obstacle due to immunologically “cold” tumors that manifest lymphocyte exhaustion or poor infiltration. Hence, exploring new therapeutic strategies to enhance antit...

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Bibliographic Details
Main Authors: Ying Gao, Lin Zuo, Yu Zheng, Keyan Sun, Yunhui Gao, Xiaobo Xu, Zengqiang Li, Daiying Zuo
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Breast Cancer Research
Subjects:
Immune checkpoint inhibitors
Immunogenicity
NOTCH1
Cellular senescence
Online Access:https://doi.org/10.1186/s13058-025-02045-2
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