A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature review
Background: Acute viral hepatitis is the most common cause of jaundice during pregnancy. Distinct immunological changes during pregnancy and the postpartum period are possible crucial factors associated with flares of chronic hepatitis B. Case: We present the case of a healthy pregnant hepatitis B v...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-07-01
|
| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/49/7/10.31083/j.ceog4907161 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850255345689034752 |
|---|---|
| author | Chih-Hsiang Yin Chia-Ching Chang Yi-Liang Lee Shou-En Wu Yi-Hsin Lin Paul Ivan Kato Chuang-Yen Huang |
| author_facet | Chih-Hsiang Yin Chia-Ching Chang Yi-Liang Lee Shou-En Wu Yi-Hsin Lin Paul Ivan Kato Chuang-Yen Huang |
| author_sort | Chih-Hsiang Yin |
| collection | DOAJ |
| description | Background: Acute viral hepatitis is the most common cause of jaundice during pregnancy. Distinct immunological changes during pregnancy and the postpartum period are possible crucial factors associated with flares of chronic hepatitis B. Case: We present the case of a healthy pregnant hepatitis B virus (HBV) carrier at 38 weeks of gestation. She underwent an emergent cesarean section due to acute hepatitis B flare, and ultimately underwent liver transplantation due to a decompensating liver based on an estimated Model for End-Stage Liver Disease score. Conclusions: For pregnant HBsAg positive women, close monitoring with serum HBV-DNA and spartate transaminase (AST)/alanine transaminase (ALT) levels every 3 months is highly recommended. According to the latest guidelines, prenatal antiviral therapy, postpartum HBV vaccination, and hepatitis B immunoglobulin should be administered to prevent mother-to-child transmission. |
| format | Article |
| id | doaj-art-37f2b97aeb2a44cd9826e8263a5cbe08 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-37f2b97aeb2a44cd9826e8263a5cbe082025-08-20T01:56:53ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632022-07-0149716110.31083/j.ceog4907161S0390-6663(22)01847-4A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature reviewChih-Hsiang Yin0Chia-Ching Chang1Yi-Liang Lee2Shou-En Wu3Yi-Hsin Lin4Paul Ivan Kato5Chuang-Yen Huang6Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, TaiwanDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, TaiwanDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, TaiwanDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, TaiwanDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, TaiwanDepartment of Obstetrics and Gynecology, Hoima Regional Referral Hospital, 7272 Hoima, UgandaDepartment of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, 114 Taipei, TaiwanBackground: Acute viral hepatitis is the most common cause of jaundice during pregnancy. Distinct immunological changes during pregnancy and the postpartum period are possible crucial factors associated with flares of chronic hepatitis B. Case: We present the case of a healthy pregnant hepatitis B virus (HBV) carrier at 38 weeks of gestation. She underwent an emergent cesarean section due to acute hepatitis B flare, and ultimately underwent liver transplantation due to a decompensating liver based on an estimated Model for End-Stage Liver Disease score. Conclusions: For pregnant HBsAg positive women, close monitoring with serum HBV-DNA and spartate transaminase (AST)/alanine transaminase (ALT) levels every 3 months is highly recommended. According to the latest guidelines, prenatal antiviral therapy, postpartum HBV vaccination, and hepatitis B immunoglobulin should be administered to prevent mother-to-child transmission.https://www.imrpress.com/journal/CEOG/49/7/10.31083/j.ceog4907161case reporthepatitis bliver transplantationpregnancy |
| spellingShingle | Chih-Hsiang Yin Chia-Ching Chang Yi-Liang Lee Shou-En Wu Yi-Hsin Lin Paul Ivan Kato Chuang-Yen Huang A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature review Clinical and Experimental Obstetrics & Gynecology case report hepatitis b liver transplantation pregnancy |
| title | A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature review |
| title_full | A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature review |
| title_fullStr | A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature review |
| title_full_unstemmed | A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature review |
| title_short | A hepatitis B virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis B: a rare case report and literature review |
| title_sort | hepatitis b virus flare that led to hepatic decompensation and liver transplantation in a pregnant woman with chronic hepatitis b a rare case report and literature review |
| topic | case report hepatitis b liver transplantation pregnancy |
| url | https://www.imrpress.com/journal/CEOG/49/7/10.31083/j.ceog4907161 |
| work_keys_str_mv | AT chihhsiangyin ahepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT chiachingchang ahepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT yilianglee ahepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT shouenwu ahepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT yihsinlin ahepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT paulivankato ahepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT chuangyenhuang ahepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT chihhsiangyin hepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT chiachingchang hepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT yilianglee hepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT shouenwu hepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT yihsinlin hepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT paulivankato hepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview AT chuangyenhuang hepatitisbvirusflarethatledtohepaticdecompensationandlivertransplantationinapregnantwomanwithchronichepatitisbararecasereportandliteraturereview |