Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation
Better understanding racial disparities observed during the COVID-19 pandemic can be aided by SARS-CoV-2 serology testing. However, racial minorities may be underrepresented in serosurveillance efforts not only due to lack of testing accessibility, but also due to hesitancy towards participating in...
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Elsevier
2025-07-01
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| Series: | Brain, Behavior, & Immunity - Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354625000778 |
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| author | Todd Lucas Christopher D. Heaney Steve W. Granger Kent D. Key Maria Knight Lapinski Nicole Jones Nigel Paneth Ahnalee M. Brincks Anurag Dawadi Leah Maschino Lindsey Rose Monicia Summers Rachel Weisbrod Nora Pisanic Olivia Aspiras Stefan M.M. Goetz Douglas A. Granger |
| author_facet | Todd Lucas Christopher D. Heaney Steve W. Granger Kent D. Key Maria Knight Lapinski Nicole Jones Nigel Paneth Ahnalee M. Brincks Anurag Dawadi Leah Maschino Lindsey Rose Monicia Summers Rachel Weisbrod Nora Pisanic Olivia Aspiras Stefan M.M. Goetz Douglas A. Granger |
| author_sort | Todd Lucas |
| collection | DOAJ |
| description | Better understanding racial disparities observed during the COVID-19 pandemic can be aided by SARS-CoV-2 serology testing. However, racial minorities may be underrepresented in serosurveillance efforts not only due to lack of testing accessibility, but also due to hesitancy towards participating in antibody testing programs stemming from medical mistrust. We designed a randomized control trial to evaluate how non-invasive salivary antibody testing and culturally targeted communication might be used to promote racial equity in uptake of SARS-CoV-2 serology testing during the COVID-19 pandemic. To evaluate these approaches, we recruited African American and White American participants from Flint, Michigan. Participants viewed a novel, animated didactic video about SARS-CoV-2 antibody testing, with half of African Americans viewing a culturally targeted version. We measured cognitive and affective responses that indicated receptivity to SARS-CoV-2 serology testing. We also provided a non-invasive salivary antibody screening opportunity, and we measured screening uptake as a behavioral outcome. Finally, we measured baseline sociodemographic, psychological, and health factors that could affect these responses. In addition to evaluating health communication approaches, multiplex SARS-CoV-2 antibody profiles can be subsequently linked to prescreen measures, and to inflammatory markers that were concomitantly measured in whole saliva. Ultimately, we aim to reduce COVID-19 racial disparities and bolster future pandemic preparedness through promoting equity in understanding and uptake of serology testing. |
| format | Article |
| id | doaj-art-37eb797b03454c8d8b66629f06239b21 |
| institution | DOAJ |
| issn | 2666-3546 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj-art-37eb797b03454c8d8b66629f06239b212025-08-20T03:21:15ZengElsevierBrain, Behavior, & Immunity - Health2666-35462025-07-014610101910.1016/j.bbih.2025.101019Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigationTodd Lucas0Christopher D. Heaney1Steve W. Granger2Kent D. Key3Maria Knight Lapinski4Nicole Jones5Nigel Paneth6Ahnalee M. Brincks7Anurag Dawadi8Leah Maschino9Lindsey Rose10Monicia Summers11Rachel Weisbrod12Nora Pisanic13Olivia Aspiras14Stefan M.M. Goetz15Douglas A. Granger16Charles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USA; Corresponding author. Charles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, 200 East 1st Street, Room 353, Flint, MI 48502, USA.Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USASalimetrics LLC, Carlsbad, CA, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USADepartment of Communication, Michigan AgBio Research, Michigan State University, East Lansing, MI, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USA; Pediatric Public Health Initiative, Charles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USADepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA; Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USADepartment of Human Development and Family Studies, Michigan State University, East Lansing, MI, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USADepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USACharles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, Flint, MI, USASalimetrics LLC, Carlsbad, CA, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USABetter understanding racial disparities observed during the COVID-19 pandemic can be aided by SARS-CoV-2 serology testing. However, racial minorities may be underrepresented in serosurveillance efforts not only due to lack of testing accessibility, but also due to hesitancy towards participating in antibody testing programs stemming from medical mistrust. We designed a randomized control trial to evaluate how non-invasive salivary antibody testing and culturally targeted communication might be used to promote racial equity in uptake of SARS-CoV-2 serology testing during the COVID-19 pandemic. To evaluate these approaches, we recruited African American and White American participants from Flint, Michigan. Participants viewed a novel, animated didactic video about SARS-CoV-2 antibody testing, with half of African Americans viewing a culturally targeted version. We measured cognitive and affective responses that indicated receptivity to SARS-CoV-2 serology testing. We also provided a non-invasive salivary antibody screening opportunity, and we measured screening uptake as a behavioral outcome. Finally, we measured baseline sociodemographic, psychological, and health factors that could affect these responses. In addition to evaluating health communication approaches, multiplex SARS-CoV-2 antibody profiles can be subsequently linked to prescreen measures, and to inflammatory markers that were concomitantly measured in whole saliva. Ultimately, we aim to reduce COVID-19 racial disparities and bolster future pandemic preparedness through promoting equity in understanding and uptake of serology testing.http://www.sciencedirect.com/science/article/pii/S2666354625000778COVID-19SARS-CoV-2Serology testingSeroNetHealth disparitiesCulturally targeted |
| spellingShingle | Todd Lucas Christopher D. Heaney Steve W. Granger Kent D. Key Maria Knight Lapinski Nicole Jones Nigel Paneth Ahnalee M. Brincks Anurag Dawadi Leah Maschino Lindsey Rose Monicia Summers Rachel Weisbrod Nora Pisanic Olivia Aspiras Stefan M.M. Goetz Douglas A. Granger Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation Brain, Behavior, & Immunity - Health COVID-19 SARS-CoV-2 Serology testing SeroNet Health disparities Culturally targeted |
| title | Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation |
| title_full | Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation |
| title_fullStr | Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation |
| title_full_unstemmed | Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation |
| title_short | Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation |
| title_sort | culturally targeted messaging and racial equity in sars cov 2 antibody testing by multiplex salivary measurement protocol overview of a seronet investigation |
| topic | COVID-19 SARS-CoV-2 Serology testing SeroNet Health disparities Culturally targeted |
| url | http://www.sciencedirect.com/science/article/pii/S2666354625000778 |
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