Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans.
In Caenorhabditis elegans (C. elegans), the promotion of longevity by the transcription factor DAF-16 requires reduced insulin/IGF receptor (IIR) signaling or the ablation of the germline, although the reason for the negative impact of germ cells is unknown. FOXO/DAF-16 activity inhibits germline pr...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002836&type=printable |
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| author | Wenjing Qi Xu Huang Elke Neumann-Haefelin Ekkehard Schulze Ralf Baumeister |
| author_facet | Wenjing Qi Xu Huang Elke Neumann-Haefelin Ekkehard Schulze Ralf Baumeister |
| author_sort | Wenjing Qi |
| collection | DOAJ |
| description | In Caenorhabditis elegans (C. elegans), the promotion of longevity by the transcription factor DAF-16 requires reduced insulin/IGF receptor (IIR) signaling or the ablation of the germline, although the reason for the negative impact of germ cells is unknown. FOXO/DAF-16 activity inhibits germline proliferation in both daf-2 mutants and gld-1 tumors. In contrast to its function as a germline tumor suppressor, we now provide evidence that somatic DAF-16 in the presence of IIR signaling can also result in tumorigenic activity, which counteracts robust lifespan extension. In contrast to the cell-autonomous IIR signaling, which is required for larval germline proliferation, activation of DAF-16 in the hypodermis results in hyperplasia of the germline and disruption of the surrounding basement membrane. SHC-1 adaptor protein and AKT-1 kinase antagonize, whereas AKT-2 and SGK-1 kinases promote, this cell-nonautonomous DAF-16 function. Our data suggest that a functional balance of DAF-16 activities in different tissues determines longevity and reveals a novel, cell-nonautonomous role of FOXO/DAF-16 to affect stem cells. |
| format | Article |
| id | doaj-art-37e82d138d914a6bb0205fb3c856f203 |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-37e82d138d914a6bb0205fb3c856f2032025-08-20T02:15:19ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042012-01-0188e100283610.1371/journal.pgen.1002836Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans.Wenjing QiXu HuangElke Neumann-HaefelinEkkehard SchulzeRalf BaumeisterIn Caenorhabditis elegans (C. elegans), the promotion of longevity by the transcription factor DAF-16 requires reduced insulin/IGF receptor (IIR) signaling or the ablation of the germline, although the reason for the negative impact of germ cells is unknown. FOXO/DAF-16 activity inhibits germline proliferation in both daf-2 mutants and gld-1 tumors. In contrast to its function as a germline tumor suppressor, we now provide evidence that somatic DAF-16 in the presence of IIR signaling can also result in tumorigenic activity, which counteracts robust lifespan extension. In contrast to the cell-autonomous IIR signaling, which is required for larval germline proliferation, activation of DAF-16 in the hypodermis results in hyperplasia of the germline and disruption of the surrounding basement membrane. SHC-1 adaptor protein and AKT-1 kinase antagonize, whereas AKT-2 and SGK-1 kinases promote, this cell-nonautonomous DAF-16 function. Our data suggest that a functional balance of DAF-16 activities in different tissues determines longevity and reveals a novel, cell-nonautonomous role of FOXO/DAF-16 to affect stem cells.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002836&type=printable |
| spellingShingle | Wenjing Qi Xu Huang Elke Neumann-Haefelin Ekkehard Schulze Ralf Baumeister Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans. PLoS Genetics |
| title | Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans. |
| title_full | Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans. |
| title_fullStr | Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans. |
| title_full_unstemmed | Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans. |
| title_short | Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans. |
| title_sort | cell nonautonomous signaling of foxo daf 16 to the stem cells of caenorhabditis elegans |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002836&type=printable |
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