Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications

Nanotechnology has emerged as a transformative field in recent years, greatly impacting medicine and healthcare with innovative solutions for complex diseases. Among these advancements, protein-based metal nanoparticles have shown exceptional promise in treating chronic illnesses, owing to their hig...

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Main Authors: Syed Muhammad Hasan, Saadat Hussain, Muhammad Yousuf, José Agustín Tapia-Hernández, Daim Asif Raja
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:International Journal of Biomaterials
Online Access:http://dx.doi.org/10.1155/ijbm/5533798
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author Syed Muhammad Hasan
Saadat Hussain
Muhammad Yousuf
José Agustín Tapia-Hernández
Daim Asif Raja
author_facet Syed Muhammad Hasan
Saadat Hussain
Muhammad Yousuf
José Agustín Tapia-Hernández
Daim Asif Raja
author_sort Syed Muhammad Hasan
collection DOAJ
description Nanotechnology has emerged as a transformative field in recent years, greatly impacting medicine and healthcare with innovative solutions for complex diseases. Among these advancements, protein-based metal nanoparticles have shown exceptional promise in treating chronic illnesses, owing to their high biocompatibility, biodegradability, customizable surface properties, and precise drug delivery capabilities. Recent studies have highlighted advancements in targeting efficiency and controlled release, alongside the ability of protein-based metal nanoparticles to bypass the first-pass metabolism, enhancing bioavailability through novel administration routes. Cutting-edge research has also focused on functionalizing protein nanostructures with therapeutic metal ions, particularly silver, with a longstanding antimicrobial and anti-inflammatory history. New combinations of silver with protein-based nanoparticles are now showing significant potential in managing chronic and life-threatening conditions. This review provides a comprehensive overview of the latest synthesis methods, toxicity assessments, therapeutic applications, administration pathways, and advanced characterization techniques for protein-based silver nanoparticles, addressing the evolving landscape of nanomedicine.
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institution Kabale University
issn 1687-8795
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series International Journal of Biomaterials
spelling doaj-art-37e602f78dc642cb8b9c366c587ebd542025-08-20T03:26:25ZengWileyInternational Journal of Biomaterials1687-87952025-01-01202510.1155/ijbm/5533798Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine ApplicationsSyed Muhammad Hasan0Saadat Hussain1Muhammad Yousuf2José Agustín Tapia-Hernández3Daim Asif Raja4Memon Medical Institute HospitalH.E.J Research Institute of ChemistryDepartment of Biomedical and Biological SciencesDepartment of Food Research and Graduate ProgramH.E.J Research Institute of ChemistryNanotechnology has emerged as a transformative field in recent years, greatly impacting medicine and healthcare with innovative solutions for complex diseases. Among these advancements, protein-based metal nanoparticles have shown exceptional promise in treating chronic illnesses, owing to their high biocompatibility, biodegradability, customizable surface properties, and precise drug delivery capabilities. Recent studies have highlighted advancements in targeting efficiency and controlled release, alongside the ability of protein-based metal nanoparticles to bypass the first-pass metabolism, enhancing bioavailability through novel administration routes. Cutting-edge research has also focused on functionalizing protein nanostructures with therapeutic metal ions, particularly silver, with a longstanding antimicrobial and anti-inflammatory history. New combinations of silver with protein-based nanoparticles are now showing significant potential in managing chronic and life-threatening conditions. This review provides a comprehensive overview of the latest synthesis methods, toxicity assessments, therapeutic applications, administration pathways, and advanced characterization techniques for protein-based silver nanoparticles, addressing the evolving landscape of nanomedicine.http://dx.doi.org/10.1155/ijbm/5533798
spellingShingle Syed Muhammad Hasan
Saadat Hussain
Muhammad Yousuf
José Agustín Tapia-Hernández
Daim Asif Raja
Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications
International Journal of Biomaterials
title Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications
title_full Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications
title_fullStr Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications
title_full_unstemmed Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications
title_short Protein-Based Silver Nanoparticles: Synthesis, Characterization, Administration, and Nanomedicine Applications
title_sort protein based silver nanoparticles synthesis characterization administration and nanomedicine applications
url http://dx.doi.org/10.1155/ijbm/5533798
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