Insulin/PHMB-grafted sodium alginate hydrogels improve infected wound healing by antibacterial-prompted macrophage inflammatory regulation

Insulin/PHMB-grafted sodium alginate hydrogels improve infected wound healing by antibacterial-prompted macrophage inflammatory regulation

Abstract Background Non-healing chronic wounds with high susceptibility to infection represent a critical challenge in modern healthcare. While growth factors play a pivotal role in regulating chronic wound repair, their therapeutic efficacy is compromised in infected microenvironments. Current woun...

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Bibliographic Details
Main Authors: Dan Liu, Tianyi Yu, Shan Ma, Lefeng Su, Shan Zhong, Wenao Wang, Yang Liu, Jia-ao Yu, Min Gao, Yunsheng Chen, He Xu, Yan Liu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Infected wound healing
Insulin
PHMB
Inflammation regulation
Skin barrier
Online Access:https://doi.org/10.1186/s12951-025-03398-8
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