Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery

Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery

Opioids have been the primary method used to manage pain for hundreds of years, however the increasing prescription rate of these drugs in the modern world has led to a public health crisis of overdose related deaths. Naloxone is the current standard treatment for opioid overdose rescue, but it has...

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Bibliographic Details
Main Authors: Aakash Patel, Suruchi Poddar, Daniel Nierenberg, Stephanie Lang, Hao Wang, Camilly Pestana Pires DeMello, Julio Gamarra, Alisha Colon, Paula Kennedy, Jeffry Roles, Jules Klion, Will Bogen, Christopher Long, Xiufang Guo, Patrick Tighe, Stephan Schmidt, Michael L. Shuler, James J. Hickman
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Toxicology
Subjects:
Microphysiological systems
Opioid overdose
Multi-organ
Body-on-a-chip
Off-target toxicity
Drug development
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000628
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