Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population
Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and T...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/650393 |
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| author | Ming-Kai Tsai Hui-Min David Wang Jeng-Chuan Shiang I-Hung Chen Chih-Chiang Wang Ya-Fen Shiao Wen-Sheng Liu Tai-Jung Lin Tsung-Ming Chen Ya-Huey Chen |
| author_facet | Ming-Kai Tsai Hui-Min David Wang Jeng-Chuan Shiang I-Hung Chen Chih-Chiang Wang Ya-Fen Shiao Wen-Sheng Liu Tai-Jung Lin Tsung-Ming Chen Ya-Huey Chen |
| author_sort | Ming-Kai Tsai |
| collection | DOAJ |
| description | Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan’s Chinese Han population, with our retrospective case-control study genotyping single nucleotide polymorphisms (SNPs) in ADIPOQ and TCF7L2 genes both in 149 T2DM patients and in 139 healthy controls from Taiwan. Statistical analysis gauged association of these polymorphisms with risk of T2DM to show ADIPOQ rs1501299 polymorphism variations strongly correlated with T2DM risk (P=0.042), with rs2241766 polymorphism being not associated with T2DM (P=0.967). However, both polymorphisms rs7903146 and rs12255372 of TCF7L2 were rarely detected in Taiwanese people. This study avers that ADIPOQ rs1501299 polymorphism contributes to risk of T2DM in the Taiwanese population. |
| format | Article |
| id | doaj-art-37d79e5040c34b69b2e23887682357fc |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-37d79e5040c34b69b2e23887682357fc2025-02-03T01:20:43ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/650393650393Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han PopulationMing-Kai Tsai0Hui-Min David Wang1Jeng-Chuan Shiang2I-Hung Chen3Chih-Chiang Wang4Ya-Fen Shiao5Wen-Sheng Liu6Tai-Jung Lin7Tsung-Ming Chen8Ya-Huey Chen9Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, TaiwanDivision of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, TaiwanDivision of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, TaiwanAsia-Pacific Biotech Developing, Inc., Kaohsiung 80681, TaiwanAsia-Pacific Biotech Developing, Inc., Kaohsiung 80681, TaiwanDepartment of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, TaiwanDepartment of Physiology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, TaiwanCenter for Molecular Medicine, China Medical University Hospital, Taichung 40477, TaiwanDiabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan’s Chinese Han population, with our retrospective case-control study genotyping single nucleotide polymorphisms (SNPs) in ADIPOQ and TCF7L2 genes both in 149 T2DM patients and in 139 healthy controls from Taiwan. Statistical analysis gauged association of these polymorphisms with risk of T2DM to show ADIPOQ rs1501299 polymorphism variations strongly correlated with T2DM risk (P=0.042), with rs2241766 polymorphism being not associated with T2DM (P=0.967). However, both polymorphisms rs7903146 and rs12255372 of TCF7L2 were rarely detected in Taiwanese people. This study avers that ADIPOQ rs1501299 polymorphism contributes to risk of T2DM in the Taiwanese population.http://dx.doi.org/10.1155/2014/650393 |
| spellingShingle | Ming-Kai Tsai Hui-Min David Wang Jeng-Chuan Shiang I-Hung Chen Chih-Chiang Wang Ya-Fen Shiao Wen-Sheng Liu Tai-Jung Lin Tsung-Ming Chen Ya-Huey Chen Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population The Scientific World Journal |
| title | Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population |
| title_full | Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population |
| title_fullStr | Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population |
| title_full_unstemmed | Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population |
| title_short | Sequence Variants of ADIPOQ and Association with Type 2 Diabetes Mellitus in Taiwan Chinese Han Population |
| title_sort | sequence variants of adipoq and association with type 2 diabetes mellitus in taiwan chinese han population |
| url | http://dx.doi.org/10.1155/2014/650393 |
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