Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice
Adverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/627837 |
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| _version_ | 1832555455517294592 |
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| author | Yaoyao Bian Lili Yang Zhongli Wang Qing Wang Li Zeng Guihua Xu |
| author_facet | Yaoyao Bian Lili Yang Zhongli Wang Qing Wang Li Zeng Guihua Xu |
| author_sort | Yaoyao Bian |
| collection | DOAJ |
| description | Adverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early phase. Early life adversity especially can alter plasticity functions. To determine whether adverse early life experiences induce changes in plasticity in the brain hippocampus, we established an MS paradigm. In this research, the mice were treated with mild (15 min, MS15) or prolonged (180 min, MS180) maternal separation from postnatal day 2 to postnatal day 21. The mice underwent a forced swimming test, a tail suspension test, and an open field test, respectively. Afterward, the mice were sacrificed on postnatal day 31 to determine the effects of MS on early life stages. Results implied that MS induces depression-like behavior and the effects may be mediated partly by interfering with the hippocampal GSK-3β-CREB signaling pathway and by reducing the levels of some plasticity-related proteins. |
| format | Article |
| id | doaj-art-37ce9528853c4004b838667314106f73 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-37ce9528853c4004b838667314106f732025-02-03T05:48:12ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/627837627837Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N MiceYaoyao Bian0Lili Yang1Zhongli Wang2Qing Wang3Li Zeng4Guihua Xu5School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaMedical College, Nantong University, Nantong 226001, ChinaSchool of Basic Medical Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaSchool of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaFirst Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaSchool of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaAdverse early life experiences can negatively affect behaviors later in life. Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS. The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early phase. Early life adversity especially can alter plasticity functions. To determine whether adverse early life experiences induce changes in plasticity in the brain hippocampus, we established an MS paradigm. In this research, the mice were treated with mild (15 min, MS15) or prolonged (180 min, MS180) maternal separation from postnatal day 2 to postnatal day 21. The mice underwent a forced swimming test, a tail suspension test, and an open field test, respectively. Afterward, the mice were sacrificed on postnatal day 31 to determine the effects of MS on early life stages. Results implied that MS induces depression-like behavior and the effects may be mediated partly by interfering with the hippocampal GSK-3β-CREB signaling pathway and by reducing the levels of some plasticity-related proteins.http://dx.doi.org/10.1155/2015/627837 |
| spellingShingle | Yaoyao Bian Lili Yang Zhongli Wang Qing Wang Li Zeng Guihua Xu Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice Neural Plasticity |
| title | Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice |
| title_full | Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice |
| title_fullStr | Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice |
| title_full_unstemmed | Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice |
| title_short | Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL/6N Mice |
| title_sort | repeated three hour maternal separation induces depression like behavior and affects the expression of hippocampal plasticity related proteins in c57bl 6n mice |
| url | http://dx.doi.org/10.1155/2015/627837 |
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