A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease

A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease

Immunomodulation of airway hyperreactivity by excretory-secretory (ES) products of the first larval stage (L1) of the gastrointestinal nematode Trichuris suis is reported by us and others. Here, we aimed to identify the proteins accounting for the modulatory effects of the T. suis L1 ES proteins and...

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Main Authors: Friederike Ebner, Katja Lindner, Katharina Janek, Agathe Niewienda, Piotr H. Malecki, Manfred S. Weiss, Tara E. Sutherland, Arnd Heuser, Anja A. Kühl, Jürgen Zentek, Andreas Hofmann, Susanne Hartmann
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2021/6234836
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