Lymphocyte/monocyte to lactate dehydrogenase ratio prior to lymphodepletion impact the outcomes of patients with diffused large B cell lymphoma undergoing CAR-T cell therapy

Lymphocyte/monocyte to lactate dehydrogenase ratio prior to lymphodepletion impact the outcomes of patients with diffused large B cell lymphoma undergoing CAR-T cell therapy

Abstract Factors associated with outcomes of chimeric antigen receptor (CAR)-T cell therapy in patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) have not been fully elucidated. We explored the impact of the prelymphodepletion (pre-LD) lymphocyte to monocyte ratio (LMR)...

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Bibliographic Details
Main Authors: Na Li, Na An, Sha Ma, Jiang Cao, Feng Zhu, Kunming Qi, Zhiling Yan, Hai Cheng, Wei Sang, Wei Chen, Depeng Li, Zhenyu Li, Kailin Xu, Ying Wang
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Diffuse large B-cell lymphoma
CAR-T cell therapy
Lymphocyte to monocyte ratio
Lactate dehydrogenase
Efficacy
Prognosis
Online Access:https://doi.org/10.1007/s00262-025-03987-4
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