Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process
The purpose of this work is to study the effects of spatio-temporal dynamics of spontaneous calcium signaling in the morphological structure of an astrocyte at the subcellular level using biophysical mathematical modeling methods. Methods. This work proposes a biophysical multicompartmental model o...
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| Format: | Article |
| Language: | English |
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Saratov State University
2025-01-01
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| Series: | Известия высших учебных заведений: Прикладная нелинейная динамика |
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| Online Access: | https://andjournal.sgu.ru/sites/andjournal.sgu.ru/files/text-pdf/2025/01/and_2025-1_ermolaeva_et-al_82-99.pdf |
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| author | Ermolaeva, Anastasia Viktorovna Kastalskiy, Innokentiy A. Kazantsev, Viktor Borisovich Gordleeva, Susanna Yurevna |
| author_facet | Ermolaeva, Anastasia Viktorovna Kastalskiy, Innokentiy A. Kazantsev, Viktor Borisovich Gordleeva, Susanna Yurevna |
| author_sort | Ermolaeva, Anastasia Viktorovna |
| collection | DOAJ |
| description | The purpose of this work is to study the effects of spatio-temporal dynamics of spontaneous calcium signaling in the morphological structure of an astrocyte at the subcellular level using biophysical mathematical modeling methods. Methods. This work proposes a biophysical multicompartmental model of noise-induced calcium dynamics in the astrocytic process. The model describes the process of generation of spontaneous Ca2+ signals induced by the stochastic activation of voltage-dependent Ca2+ channels on the plasma membrane of the astrocyte. The model allows us to study the dynamics of the propagation of spontaneous local Ca2+ signals and the mechanisms of formation of spatial Ca2+ patterns in the astrocytic process. Results. The developed model enables studying the influence of morphology and intracellular biophysical mechanisms on the characteristics of spontaneous noise-induced Ca2+ signaling in the astrocytic process. The parameter ranges at which the model qualitatively reproduces the spontaneous Ca2+ activity at the subcellular level observed in experimental studies have been specified. The characteristics of noise-induced Ca2+ patterns propagating along the process were investigated, depending on the internal structure of the process, its geometry, and the steady state concentration of inositol 1,4,5-triphosphate molecules. |
| format | Article |
| id | doaj-art-37c7d288bcd949749c5ffbf1dc0675e8 |
| institution | Kabale University |
| issn | 0869-6632 2542-1905 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Saratov State University |
| record_format | Article |
| series | Известия высших учебных заведений: Прикладная нелинейная динамика |
| spelling | doaj-art-37c7d288bcd949749c5ffbf1dc0675e82025-01-31T04:16:49ZengSaratov State UniversityИзвестия высших учебных заведений: Прикладная нелинейная динамика0869-66322542-19052025-01-01331829910.18500/0869-6632-003125Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic processErmolaeva, Anastasia Viktorovna0Kastalskiy, Innokentiy A.1Kazantsev, Viktor Borisovich2Gordleeva, Susanna Yurevna3Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Gagarin Avenue, 23Lobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Gagarin Avenue, 23Institute of Applied Physics of the Russian Academy of Sciences, ul. Ul'yanova, 46, Nizhny Novgorod , 603950, RussiaLobachevsky State University of Nizhny Novgorod, 603950 Nizhny Novgorod, Gagarin Avenue, 23The purpose of this work is to study the effects of spatio-temporal dynamics of spontaneous calcium signaling in the morphological structure of an astrocyte at the subcellular level using biophysical mathematical modeling methods. Methods. This work proposes a biophysical multicompartmental model of noise-induced calcium dynamics in the astrocytic process. The model describes the process of generation of spontaneous Ca2+ signals induced by the stochastic activation of voltage-dependent Ca2+ channels on the plasma membrane of the astrocyte. The model allows us to study the dynamics of the propagation of spontaneous local Ca2+ signals and the mechanisms of formation of spatial Ca2+ patterns in the astrocytic process. Results. The developed model enables studying the influence of morphology and intracellular biophysical mechanisms on the characteristics of spontaneous noise-induced Ca2+ signaling in the astrocytic process. The parameter ranges at which the model qualitatively reproduces the spontaneous Ca2+ activity at the subcellular level observed in experimental studies have been specified. The characteristics of noise-induced Ca2+ patterns propagating along the process were investigated, depending on the internal structure of the process, its geometry, and the steady state concentration of inositol 1,4,5-triphosphate molecules.https://andjournal.sgu.ru/sites/andjournal.sgu.ru/files/text-pdf/2025/01/and_2025-1_ermolaeva_et-al_82-99.pdfastrocytic processcompartmentcalcium signalinositol 145-triphosphateanomalous diffusion |
| spellingShingle | Ermolaeva, Anastasia Viktorovna Kastalskiy, Innokentiy A. Kazantsev, Viktor Borisovich Gordleeva, Susanna Yurevna Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process Известия высших учебных заведений: Прикладная нелинейная динамика astrocytic process compartment calcium signal inositol 1 4 5-triphosphate anomalous diffusion |
| title | Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process |
| title_full | Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process |
| title_fullStr | Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process |
| title_full_unstemmed | Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process |
| title_short | Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process |
| title_sort | effects of the dynamics of noise induced calcium signals in a biophysical model of the astrocytic process |
| topic | astrocytic process compartment calcium signal inositol 1 4 5-triphosphate anomalous diffusion |
| url | https://andjournal.sgu.ru/sites/andjournal.sgu.ru/files/text-pdf/2025/01/and_2025-1_ermolaeva_et-al_82-99.pdf |
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