Effects of the dynamics of noise-induced calcium signals in a biophysical model of the astrocytic process
The purpose of this work is to study the effects of spatio-temporal dynamics of spontaneous calcium signaling in the morphological structure of an astrocyte at the subcellular level using biophysical mathematical modeling methods. Methods. This work proposes a biophysical multicompartmental model o...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Saratov State University
2025-01-01
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| Series: | Известия высших учебных заведений: Прикладная нелинейная динамика |
| Subjects: | |
| Online Access: | https://andjournal.sgu.ru/sites/andjournal.sgu.ru/files/text-pdf/2025/01/and_2025-1_ermolaeva_et-al_82-99.pdf |
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| Summary: | The purpose of this work is to study the effects of spatio-temporal dynamics of spontaneous calcium signaling in the morphological structure of an astrocyte at the subcellular level using biophysical mathematical modeling methods. Methods. This work proposes a biophysical multicompartmental model of noise-induced calcium dynamics in the astrocytic process. The model describes the process of generation of spontaneous Ca2+ signals induced by the stochastic activation of voltage-dependent Ca2+ channels on the plasma membrane of the astrocyte. The model allows us to study the dynamics of the propagation of spontaneous local Ca2+ signals and the mechanisms of formation of spatial Ca2+ patterns in the astrocytic process. Results. The developed model enables studying the influence of morphology and intracellular biophysical mechanisms on the characteristics of spontaneous noise-induced Ca2+ signaling in the astrocytic process. The parameter ranges at which the model qualitatively reproduces the spontaneous Ca2+ activity at the subcellular level observed in experimental studies have been specified. The characteristics of noise-induced Ca2+ patterns propagating along the process were investigated, depending on the internal structure of the process, its geometry, and the steady state concentration of inositol 1,4,5-triphosphate molecules. |
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| ISSN: | 0869-6632 2542-1905 |