circ-0001875 downregulation is associated with M1 macrophage activation and lung inflammation in severe asthma

circ-0001875 downregulation is associated with M1 macrophage activation and lung inflammation in severe asthma

BackgroundAsthma is a heterogeneous group of diseases. The mechanism by which dysregulated circRNAs affect severe asthma by regulating macrophage polarization remains unclear.MethodsHigh-throughput RNA sequencing technology was used to analyze circRNA expression in peripheral blood mononuclear cells...

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Bibliographic Details
Main Authors: Gege Liu, Jiahao Cao, Yiyan Lin, Bingyu Long, Yanyu Su, Guiqiang Qiu, Chi Jiang, Yue Wang, Xuanna Zhao, Dan Huang, Dong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
severe asthma
circ-0001875
miR-31-5p
SP1
M1 polarization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601272/full
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