The Inhibition of Prolyl Endopeptidase (PREP) by KYP-2047 Treatment to Reduce Myocardial Ischemia/Reperfusion Injury

The Inhibition of Prolyl Endopeptidase (PREP) by KYP-2047 Treatment to Reduce Myocardial Ischemia/Reperfusion Injury

Myocardial ischemia–reperfusion injury (MI/R) is a negative and adverse cardiovascular outcome following myocardial ischemia, cardiac surgery, or circulatory arrest. Prolyl endopeptidase (PREP) appears to be involved in inflammatory responses, so it could be a possible therapeutic target for counter...

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Bibliographic Details
Main Authors: Laura Cucinotta, Nicoletta Palermo, Alessio Ardizzone, Anna Paola Capra, Michela Campolo, Emanuela Esposito, Giovanna Casili, Marika Lanza
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Antioxidants
Subjects:
myocardial ischemia/reperfusion injury (MI/R)
prolyl endopeptidase
KYP-2047
MAPK
NF-κB
Online Access:https://www.mdpi.com/2076-3921/14/4/442
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