B-Cell Response during Protozoan Parasite Infections
In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In ad...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2012/362131 |
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| author | María C. Amezcua Vesely Daniela A. Bermejo Carolina L. Montes Eva V. Acosta-Rodríguez Adriana Gruppi |
| author_facet | María C. Amezcua Vesely Daniela A. Bermejo Carolina L. Montes Eva V. Acosta-Rodríguez Adriana Gruppi |
| author_sort | María C. Amezcua Vesely |
| collection | DOAJ |
| description | In this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity are affected during the protozoan parasite infection. Moreover, some trypanosomatides trigger bone marrow immature B cell apoptosis, influencing the generation of new mature B cells. Simultaneously with their ability to release antibodies, B cells produce cytokines/quemokines that influence the characteristic of cellular immune response and consequently the progression of parasite infections. |
| format | Article |
| id | doaj-art-37bf136f4cb84e3b901009943009dadc |
| institution | DOAJ |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-37bf136f4cb84e3b901009943009dadc2025-08-20T03:20:29ZengWileyJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/362131362131B-Cell Response during Protozoan Parasite InfectionsMaría C. Amezcua Vesely0Daniela A. Bermejo1Carolina L. Montes2Eva V. Acosta-Rodríguez3Adriana Gruppi4Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5000 Córdoba, ArgentinaCentro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5000 Córdoba, ArgentinaCentro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5000 Córdoba, ArgentinaCentro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5000 Córdoba, ArgentinaCentro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5000 Córdoba, ArgentinaIn this review, we discuss how protozoan parasites alter immature and mature B cell compartment. B1 and marginal zone (MZ) B cells, considered innate like B cells, are activated during protozoan parasite infections, and they generate short lived plasma cells providing a prompt antibody source. In addition, protozoan infections induce massive B cell response with polyclonal activation that leads to hypergammaglobulnemia with serum antibodies specific for the parasites and self and/or non related antigens. To protect themselves, the parasites have evolved unique ways to evade B cell immune responses inducing apoptosis of MZ and conventional mature B cells. As a consequence of the parasite induced-apoptosis, the early IgM response and an already establish humoral immunity are affected during the protozoan parasite infection. Moreover, some trypanosomatides trigger bone marrow immature B cell apoptosis, influencing the generation of new mature B cells. Simultaneously with their ability to release antibodies, B cells produce cytokines/quemokines that influence the characteristic of cellular immune response and consequently the progression of parasite infections.http://dx.doi.org/10.1155/2012/362131 |
| spellingShingle | María C. Amezcua Vesely Daniela A. Bermejo Carolina L. Montes Eva V. Acosta-Rodríguez Adriana Gruppi B-Cell Response during Protozoan Parasite Infections Journal of Parasitology Research |
| title | B-Cell Response during Protozoan Parasite Infections |
| title_full | B-Cell Response during Protozoan Parasite Infections |
| title_fullStr | B-Cell Response during Protozoan Parasite Infections |
| title_full_unstemmed | B-Cell Response during Protozoan Parasite Infections |
| title_short | B-Cell Response during Protozoan Parasite Infections |
| title_sort | b cell response during protozoan parasite infections |
| url | http://dx.doi.org/10.1155/2012/362131 |
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