Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume)
Objective: To investigate potential associations of preoperative total testosterone (TT) with tumor volume (TV) and grade of prostate cancer (PCa). Methods: Patients who were under medications impacting on the hypothalamic-pituitary-adrenal-testis-prostate axis were excluded. TT was measured preoper...
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Elsevier
2016-01-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388215001228 |
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| author | Antonio B. Porcaro Aldo Petrozziello Matteo Brunelli Filippo Migliorini Giovanni Cacciamani Davide De Marchi Nicolo' de Luyk Irene Tamanini Beatrice Caruso Maria A. Cerruto Claudio Ghimenton Walter Artibani |
| author_facet | Antonio B. Porcaro Aldo Petrozziello Matteo Brunelli Filippo Migliorini Giovanni Cacciamani Davide De Marchi Nicolo' de Luyk Irene Tamanini Beatrice Caruso Maria A. Cerruto Claudio Ghimenton Walter Artibani |
| author_sort | Antonio B. Porcaro |
| collection | DOAJ |
| description | Objective: To investigate potential associations of preoperative total testosterone (TT) with tumor volume (TV) and grade of prostate cancer (PCa).
Methods: Patients who were under medications impacting on the hypothalamic-pituitary-adrenal-testis-prostate axis were excluded. TT was measured preoperatively at least 1 month after biopsies and TV was calculated on the removed prostate specimen. Other continuous variables included total prostate specific antigen (PSA), percentage of positive cores (P+) and weight (W) of the removed prostate. Patients were categorized according to the pathologic Gleason score (pGS) in 3 groups (pGS 6, 7 and > 7). Invasion of the seminal vesicles was coded as seminal vesicle invasion (SVI).
Results: The median levels of TT were significantly and increasingly higher from pGS 6 (14.7 nmol/L) to pGS 7 (15.0 nmol/L) and pGS > 7 (18.8 nmol/L). The median values of TV were also detected significantly and increasingly higher from pGS 6 (5.6 mL) to pGS 7 (8.1 mL) and pGS > 7 (14.8 mL). The median preoperative levels of PSA were also increasing from pGS 6 (5.9 μg/L) to pGS 7 (6.2 μg/L) and pGS > 7 (7.7 μg/L). There was a significant and positive correlation of TV to PSA, TT and P+. Multiple linear regression analysis showed that TV was significantly and independently predicted by TT, PSA and P+. High grade PCa (pGS > 7) independently associated with TV, TT, P+ and SVI. The median density values of TT relative to TV (quotient TT/TV) significantly decreased from pGS 6 (2.6 nmol/L/mL) to pGS 7 (1.9 nmol/L/mL) and pGS > 7 (1.4 nmol/L/mL). The median density values of PSA relative to TV (quotient PSA/TV) also significantly decreased from pGS (1.1 μg/L/mL) to pGS 7 (0.7 μg/L/mL) and pGS > 7 (0.6 μg/L/mL).
Conclusion: The investigation shows that TT relates to volume and grade of PCa; moreover, the density of TT relative to TV inversely associates with rate of increase of cancer that depends on the grade of the tumour. |
| format | Article |
| id | doaj-art-37b73225719a4ecbabfb675a7390ab21 |
| institution | DOAJ |
| issn | 2214-3882 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
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| series | Asian Journal of Urology |
| spelling | doaj-art-37b73225719a4ecbabfb675a7390ab212025-08-20T03:20:29ZengElsevierAsian Journal of Urology2214-38822016-01-0131263210.1016/j.ajur.2015.11.006Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume)Antonio B. Porcaro0Aldo Petrozziello1Matteo Brunelli2Filippo Migliorini3Giovanni Cacciamani4Davide De Marchi5Nicolo' de Luyk6Irene Tamanini7Beatrice Caruso8Maria A. Cerruto9Claudio Ghimenton10Walter Artibani11Clinica Urologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyMedicina Interna/Endocrinologia, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyAnatomia Patologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyClinica Urologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyClinica Urologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyClinica Urologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyClinica Urologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyClinica Urologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyMedicina di Laboratorio, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyClinica Urologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyAnatomia Patologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyClinica Urologica, Ospedale Policlinico ed Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyObjective: To investigate potential associations of preoperative total testosterone (TT) with tumor volume (TV) and grade of prostate cancer (PCa). Methods: Patients who were under medications impacting on the hypothalamic-pituitary-adrenal-testis-prostate axis were excluded. TT was measured preoperatively at least 1 month after biopsies and TV was calculated on the removed prostate specimen. Other continuous variables included total prostate specific antigen (PSA), percentage of positive cores (P+) and weight (W) of the removed prostate. Patients were categorized according to the pathologic Gleason score (pGS) in 3 groups (pGS 6, 7 and > 7). Invasion of the seminal vesicles was coded as seminal vesicle invasion (SVI). Results: The median levels of TT were significantly and increasingly higher from pGS 6 (14.7 nmol/L) to pGS 7 (15.0 nmol/L) and pGS > 7 (18.8 nmol/L). The median values of TV were also detected significantly and increasingly higher from pGS 6 (5.6 mL) to pGS 7 (8.1 mL) and pGS > 7 (14.8 mL). The median preoperative levels of PSA were also increasing from pGS 6 (5.9 μg/L) to pGS 7 (6.2 μg/L) and pGS > 7 (7.7 μg/L). There was a significant and positive correlation of TV to PSA, TT and P+. Multiple linear regression analysis showed that TV was significantly and independently predicted by TT, PSA and P+. High grade PCa (pGS > 7) independently associated with TV, TT, P+ and SVI. The median density values of TT relative to TV (quotient TT/TV) significantly decreased from pGS 6 (2.6 nmol/L/mL) to pGS 7 (1.9 nmol/L/mL) and pGS > 7 (1.4 nmol/L/mL). The median density values of PSA relative to TV (quotient PSA/TV) also significantly decreased from pGS (1.1 μg/L/mL) to pGS 7 (0.7 μg/L/mL) and pGS > 7 (0.6 μg/L/mL). Conclusion: The investigation shows that TT relates to volume and grade of PCa; moreover, the density of TT relative to TV inversely associates with rate of increase of cancer that depends on the grade of the tumour.http://www.sciencedirect.com/science/article/pii/S2214388215001228Total testosteroneTumour volumeProstate-specific antigenProstate cancerPathology Gleason score |
| spellingShingle | Antonio B. Porcaro Aldo Petrozziello Matteo Brunelli Filippo Migliorini Giovanni Cacciamani Davide De Marchi Nicolo' de Luyk Irene Tamanini Beatrice Caruso Maria A. Cerruto Claudio Ghimenton Walter Artibani Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume) Asian Journal of Urology Total testosterone Tumour volume Prostate-specific antigen Prostate cancer Pathology Gleason score |
| title | Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume) |
| title_full | Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume) |
| title_fullStr | Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume) |
| title_full_unstemmed | Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume) |
| title_short | Prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities (quotient testosterone/tumour volume) |
| title_sort | prostate cancer volume associates with preoperative plasma levels of testosterone that independently predicts high grade tumours which show low densities quotient testosterone tumour volume |
| topic | Total testosterone Tumour volume Prostate-specific antigen Prostate cancer Pathology Gleason score |
| url | http://www.sciencedirect.com/science/article/pii/S2214388215001228 |
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